TOTAL SYNTHESIS OF APHIDICOLN, A POTENT ANTITUMOR AGENT

本研究的目的是发展综合方法学， 新的双迈克尔环化和手性转移将使 抗肿瘤剂Aphidicolin以有效的方式合成。 该项目的成功完成将提供一种方法， 生产这种有前途的新药的充足供应，以及 提供合成类似物，其将可用于测试， 抗肿瘤剂和抗有丝分裂剂。 该项目旨在提供新的 合成方法，这将是通用的领域， 化学合成

The aim of this research is to develop synthetic methodology involving a new double Michael cyclization and chirality transfer which will allow the antitumor agent Aphidicolin to be synthesized in an efficient manner. Successful completion of this project will provide a method for the production of an abundant supply of this promising new drug, as well as providing synthetic analogs which will be available for testing as antitumor and antimitotic agents. This project is designed to provide new synthetic methodology which will be of general utility in the field of chemical synthesis.