CLEAVABLE SURFACTANT-BASED VESICLES FOR CANCER TREATMENT

拟议研究的总体目标是开发 用于靶向的新型聚合和非聚合囊泡系统 癌症治疗中的药物输送。这些系统将基于 关于可裂解表面活性剂。如果一种表面活性物质中含有 将其亲水和亲油部分分开的连接，即 在某些条件下稳定，但在其他条件下不稳定。卵裂在 该键将表面活性剂转化为非表面活性剂 化合物，因此这将导致可劈裂的断裂 伴随着AN的释放的基于表面活性剂的囊泡 被困化合物。酸碱度和紫外线敏感度都将是 受雇的。前者将允许靶向肿瘤，这可以 比正常组织的pH值低。它的确切性质是 连接和聚合/非聚合特性将是 变化以产生一系列具有广泛光谱的靶向囊泡 如果不是这样的话，释放动力学是困难的 不可能得到的。 具体目标如下：(1)双链的制备， 可裂解表面活性剂和聚合类似物； 聚合态和非聚合态囊泡的表征 由它们制成；(3)证明这些囊泡 在癌症治疗中具有药物输送的潜力。

The overall goal of the proposed research is the development of novel polymerized and unpolymerized vesicle systems for targeted drug delivery in cancer treatment. These systems will be based on cleavable surfactants. A surfactant is cleavable if it contains a linkage separating its hydrophilic and lipophilic portions that is stable under some conditions but labile under others. Cleavage at the linkage converts the surfactant into non-surfactant compounds, and it would therefore result in rupture of a cleavable surfactantbased vesicle with concomitant release of an entrapped compound. Both pH and UVsensitive linkages will be employed. The former will allow targeting to tumors, which can have lower pH's than normal tissue. The exact nature of the linkage and the polymerized/unpolymerized character will be varied to give a series of targeted vesicles with a wide spectrum of release kinetics that would otherwise be difficult if not impossible to obtain. Detailed goals are as follows: (1) the preparation of doublechain, cleavable surfactants and polymerized analogues; (2) the characterization of polymerized and unpolymerized vesicles formulated from them; (3) the demonstration that such vesicles have potential for drug delivery in cancer treatment.