CLEAVABLE SURFACTANT-BASED VESICLES FOR CANCER TREATMENT

拟议研究的总体目标是开发 用于靶向治疗的新型聚合和未聚合囊泡系统 癌症治疗中的药物输送。 这些系统将基于 可裂解的表面活性剂。 如果表面活性剂含有 分离其亲水和亲脂部分的键， 在某些条件下稳定，但在其他条件下不稳定。 处的裂解 该连接将表面活性剂转化为非表面活性剂 因此，它会导致一个可分裂的化合物的破裂， 基于表面活性剂的囊泡， 包封化合物。 pH和UV敏感性连接将是 就业。 前者将允许靶向肿瘤， 比正常组织的pH值要低 的确切性质 连接和聚合/未聚合的字符将是 变化以产生一系列具有广泛谱的靶向囊泡 释放动力学，否则将是困难的， 不可能获得。 具体目标如下：（1）编写双链， 可裂解的表面活性剂和聚合的类似物;（2） 聚合和未聚合囊泡的表征 （3）证明这种囊泡 在癌症治疗中具有药物输送的潜力。

The overall goal of the proposed research is the development of novel polymerized and unpolymerized vesicle systems for targeted drug delivery in cancer treatment. These systems will be based on cleavable surfactants. A surfactant is cleavable if it contains a linkage separating its hydrophilic and lipophilic portions that is stable under some conditions but labile under others. Cleavage at the linkage converts the surfactant into non-surfactant compounds, and it would therefore result in rupture of a cleavable surfactantbased vesicle with concomitant release of an entrapped compound. Both pH and UVsensitive linkages will be employed. The former will allow targeting to tumors, which can have lower pH's than normal tissue. The exact nature of the linkage and the polymerized/unpolymerized character will be varied to give a series of targeted vesicles with a wide spectrum of release kinetics that would otherwise be difficult if not impossible to obtain. Detailed goals are as follows: (1) the preparation of doublechain, cleavable surfactants and polymerized analogues; (2) the characterization of polymerized and unpolymerized vesicles formulated from them; (3) the demonstration that such vesicles have potential for drug delivery in cancer treatment.