QUALITY OF LIFE FOLLOWING BONE MARROW TRANSPLANTATION

骨髓移植（BMT）作为治疗各种 近年来，威胁生命的疾病显著增加。前景 骨髓移植后的长期存活率也有所提高。然而，尽管如此， 对幸存者的生活质量知之甚少， 同种异体骨髓移植对幸存者的生活质量一无所知。 自体骨髓移植现有的研究表明， 成年BMT幸存者的生活质量。虽然有些病人很少表现出 BMT后并发症和证据基本上是“正常”的质量， 生活中，其他病人的证据各种残留的困难。知识 BMT后的生活质量是必不可少的（a）知情的过程 （B）确定骨髓移植后的康复需求， 制定干预措施，以提高骨髓移植后的生活质量，以及（c） 分析与BMT相关的相对成本和收益。使用 回顾性，纵向设计，拟议的研究将评估 150例成人BMT患者样本中至少1年的生活质量 骨髓移植后所有患者都将接受自体或异体移植。 骨髓移植治疗恶性疾病。BMT幸存者将从5个不同的 BMT中心。75例肾移植存活者的匹配对照样本 还将评估移植（RT）。BMT患者将完成 电话访问和一套问卷调查， 18-一个月的跟踪评估。RT患者将只完成 两次评估的问卷调查。建议的总体目标 研究是（a）确定成年人的生活质量 BMT的幸存者在各种结果领域，包括 身体、社会、心理和职业，以及（B）识别 患者、疾病和治疗相关变量， BMT后患者间生活质量的变异性。的具体目标 建议的研究包括（a）比较生活质量的结果， 自体和同种异体BMT的存活者，（B）检查颞叶 BMT后功能恢复和生活质量的轨迹，以及（c） BMT后生活质量与BMT后生存者的生活质量比较 RT是一种类似的医疗程序， 可接受的生活质量结果。

The use of bone marrow transplantation (BMT) as treatment for a variety of life threatening diseases has increased markedly in recent years. Prospects for longterm survival following BMT have also increased. Nevertheless, little is known about the quality of life evidenced by survivors of allogeneic BMT. Nothing is known about the quality of life of survivors of autologous BMT. The scant research that exists suggests wide variability in the quality of life of adult BMT survivors. While some patients exhibit few post-BMT complications and evidence an essentially "normal" quality of life, other patients evidence a variety of residual difficulties. Knowledge of post-BMT quality of life is essential for (a) the process of informed consent, (b) identification of post-BMT rehabilitation needs and the development of interventions to enhance post-BMT quality of life, and (c) analysis of the relative costs and benefits associated with BMT. Using a retrospective, longitudinal design, the proposed research will assess quality of life in a sample of 150 adult BMT patients at least 1 year post-BMT. All patients will have undergone either autologous or allogeneic BMT for a malignant disease. BMT survivors will be drawn from 5 different BMT centers. A matched comparison sample of 75 survivors of renal transplantation (RT) will also be assessed. BMT patients will complete a telephone interview and a packet of questionnaires at both an initial and 18-month follow-up assessment. RT patients will complete only the packet of questionnaires at both assessments. The overall aims of the proposed research are the (a) identification of the quality of life of adult survivors of BMT across a variety of outcome domains including the physical, social, psychological, and occupational, and (b) identification of patient-, disease-, and treatment-related variables associated with interpatient variability in post-BMT quality of life. Specific aims of the proposed research include (a) comparison of quality of life outcomes in survivors of autologous and allogeneic BMT, (b) examination of the temporal trajectory of post-BMT functional recovery and quality of life, and (c) comparison of post-BMT quality of life with that evidenced by survivors of RT, an analogous medical procedure with previously established and acceptable quality of life outcomes.