MAGNETIC RESONANCE CHARACTERISTICS OF TMJ TISSUES

目前的技术，用于评估内部紊乱的 颞下颌关节（TMJ）需要结合X线片 程序，包括经颅或全景X射线，断层扫描， 关节造影可能还有CT 磁共振成像（MRI）是一种 用于观察关节软组织的替代技术， 暴露于电离辐射。 人TMJ的初步MR扫描（1.5 特斯拉，使用6厘米表面线圈信号探测器）产生高度详细的 图像. 然而，准确识别小结构内的 关节囊，如半月板的切片，需要进一步研究 在临床应用之前。 因为磁共振成像是基于信号 这反映了与它们相关的组织的复杂特征。 生理学和结构，个体之间和个体之间的差异 可能出现健康和患病的结构。 有限的数据目前 可用的相关MR信号强度和组织特性。 这 该项目将调查MR在检测脑功能紊乱方面的潜在用途 颞下颌关节软组织，并提供有关程度的信息， 半月板和后韧带组织中的病理学。 解剖关系所示的新鲜尸体颞下颌关节的磁共振图像将是 与大体形态学、解剖学和组织学评价进行比较。 此外，新鲜的，手术切除的 踝关节和后韧带组织将与详细 使用标准组织学方法对这些组织进行组织学评估 程序和立体图像分析。 最后，对一个 有和无囊内病变的人类受试者数量有限 将进行验证，以证实体外研究的结果， 确定未来临床疗效研究的适当性 颞下颌关节特殊形态的MRI评价 功能障碍 将获得手术验证和组织样本 2/3的受试者。 这项研究代表了Penna大学之间的合作。 医学院及牙科医学院及牙科学院 纽约州立大学在布法罗。 Penna大学的研究人员。有 广泛的专业知识和独特的磁共振MR成像设施 研究，而S.U.N.Y.拥有先进的自动化 组织学设备和TMJ患者的大量资源。

Current techniques for evaluation of internal derangements of the temporomandibular joint (TMJ) require a combination of radiograph procedures, including transcranial or pantographic x-rays, tomograms, arthrography and possibly CT. Magnetic resonance imaging (MRI) is an alternative technique for viewing the soft tissues of the joint without exposure to ionizing radiation. Preliminary MR scans of human TMJ's (1.5 Tesla, using 6 cm surface coils signal detectors) produced highly detailed images. However, accurate identification of small structures within the joint capsule, such as the sections of the meniscus, requires further study prior to clinical application. Because the MR image is based on signals which reflect complex characteristics of the tissues related to their physiology as well as structure, variations between individuals and between healthy and diseased structures may occur. Limited data is currently available relating MR signal strength and tissue characteristics. This project will investigate the potential use of MR to detect derangement of the TMJ soft tissues and to provide information regarding the degree of pathology in the meniscus and posterior ligament tissues. Anatomic relationships as shown in MR images of fresh cadaver TMJ's will be compared with gross morphology, dissection and histological evaluation. Further, the MR signal characteristics of fresh, surgically excised meniscal and posterior ligament tissue will be correlated with detailed histological assessment of these tissues using standard histological procedures and stereometric image analysis. Finally, MR scanning of a limited number of human subjects with and without intracapsular pathology will be performed to corroborate the results of the in vitro studies and determine the appropriateness of future studies of the clinical efficacy of MRI for evaluation of specific forms of temporomandibular joint dysfunction. Surgical verification and tissue samples will be obtained from 2/3 of the subjects. This investigation represents a collaboration between the Univ. of Penna. Schools of Medicine and Dental Medicine and the School of Dentistry at the S.U.N.Y. at Buffalo. The investigators at the Univ. of Penna. have extensive expertise and unique MR imaging facilities for magnetic resonance studies, while the investigators at S.U.N.Y. have sophisticated automated histology equipment and a large resource for TMJ patients.