3-D ANALYSIS OF AUDITORY BRAINSTEM RESPONSE IN HUMANS

这个项目的总体目标是促进 在人类身上记录的ABR(听觉脑干反应)，基于 多声道录音的最新发展。几条研究路线 将会被追查。首先，将确定人类的ABR是否在 全部或部分可以被建模为等效的偶极子。人类将成为 研究了放置在头皮上的电极的记录 标准的10-20系统。将使用两条证据来确定 电势与偏心偶极子发电机一致：a) 两种不同电极估计偶极子发生器的比较 数组。B)ABR表面电势分布的比较 每个时间点，用放置在 从受试者头部模制而成的体积导体。测试的测试 内听觉中与偶极子相关的表面电位分布 Meatus也将有助于这个问题，即是否会出现第二波 ABR是由于第七神经动作电位进入颅骨所致。 其次，研究了信号滤波对ABR波形的影响 因为它们影响等价物的方向、大小或检测 偶极子。 第三，肌肉伪影对记录在 不同的头皮位置将被确定，以及近场是否 肌肉记录提供了排除含有伪影的更好的方法 扫荡。 最后，对不同电极位置的信噪比进行了比较 记录人类的ABR将被研究，以确定 电极的最佳位置。 这项研究与ABR的医疗用途直接相关， 包括新生儿、婴儿和成人听力障碍的诊断，如 以及儿童和成人神经异常的诊断。

The overall goal of this project is to advance basic science knowledge of the ABR (Auditory Brainstem Response), recorded in humans, based upon recent developments in multi-channel recordings. Several lines of research will be pursued. First, it will be determined whether the ABR in humans, in whole or in part, can be modelled as an equivalent dipole. Humans will be studied recording from electrodes placed on the scalp according to the standard 10-20 system. Two lines of evidence will be used to determine if the potentials are consistent with an eccentric dipole generator: a) comparison of the dipole generator estimated from two different electrode arrays. b) comparison of the surface potential distribution of the ABR at each point in time, with potentials recorded from dipoles placed in a volume-conductor molded from the head of the subject. The testing of surface potential distribution related to a dipole in the internal auditory meatus will also contribute to the question as to whether wave II of the ABR is due to the VIIIth nerve action potential entering the cranium. Second, the effects of signal filters on the ABR waveforms will be studied as they affect the orientation, magnitude, or detection of the equivalent dipole. Third, the effects of muscle artifacts on the potentials recorded at different scalp locations will be determined, as well as whether nearfield muscle recordings provide a better means of excluding artifact-containing sweeps. Finally, the signal-to-noise ratio of different electrode locations for recording the ABR in humans will be studied in order to determine the optimal locations for electrodes. This research is directly related to the medical uses of the ABR, which includes diagnosis of hearing deficits in newborns, infants, and adults, as well as diagnosis of neurological abnormalities in children and adults.