Novel nano-composite particles for controlled-release drugs via inhalation

该项目将探索一种新的纳米药物技术，使用脂质体中的纳米晶体来设计新的复合颗粒，使抗生素能够通过吸入获得最佳释放。由多重耐药细菌引起的呼吸道感染是世界范围内的一个主要健康问题。使用脂质体的控释产品简化了给药方案并增强了对细菌的杀灭。目前，雾化脂质体仅限于液体形式，对释放和稳定性的控制有限。该项目将提供制造抗生素复合粉末的新技术，最终可能导致开发有效的抗药性细菌新疗法。

This project will explore a novel nano-medicine technology using nanocrystals in liposomes to design new composite particles to enable optimal release of antibiotics delivered by inhalation. Respiratory infection caused by multidrug-resistant bacteria is a major health problem worldwide. Controlled-release products using liposomes simplify dose regimen and enhance bacterial killing. Currently, aerosolised liposomes are limited to liquid forms with limited control over release and stability. The project will provide new technology on manufacturing composite powders of antibiotics that may ultimately lead to the development of effective new treatments against drug-resistant bacteria.