MAGNETIC RESONANCE CHARACTERISTICS OF TMJ TISSUES

目前用于评估心脏内部排列紊乱的技术 颞下颌关节(TMJ)需要结合X光片 程序，包括经颅或受电弓X光，断层摄影， 关节造影术，可能还有CT。磁共振成像(MRI)是一种 查看关节软组织的另一种技术 暴露在电离辐射中。人类TMJ(1.5)的初步MR扫描 特斯拉，使用6厘米表面线圈信号探测器)产生了非常详细的 图像。然而，准确识别 关节囊，如半月板的部分，需要进一步研究。 在临床应用之前。因为磁共振图像是基于信号的 它们反映了与其相关的组织的复杂特征 生理和结构，个体之间和个体之间的差异 可能会出现健康和患病的结构。有限的数据目前 可将磁共振信号强度和组织特征联系起来。这 该项目将调查磁共振的潜在用途，以检测脑电活动异常 TMJ软组织，并提供有关程度的信息 半月板和后韧带组织的病理学。 新鲜身体TMJ的磁共振图像显示的解剖关系将是 并与大体形态、解剖及组织学评价进行比较。 此外，新鲜的、手术切除的肿瘤的磁共振信号特征 半月板和后韧带组织将与详细的 用标准组织学方法对这些组织进行组织学评估 程序和立体图像分析。最后，MR扫描一个 有限数量的患有和不患有囊内病变的人类受试者 将进行检查以证实体外研究的结果和 确定未来临床疗效研究的适宜性 MRI对特定形态的颞下颌关节的评价 功能障碍。将获得手术验证和组织样本 来自三分之二的受试者。 这项调查代表了大学之间的合作。佩纳的名字。 大学医学院和牙科医学院及牙医学院 纽约大学布法罗分校。大学的调查人员。佩纳的名字。有 广博的专业知识和独特的磁共振成像设备 研究，而纽约大学的调查人员拥有复杂的自动化 组织学设备和为TMJ患者提供的大量资源。

Current techniques for evaluation of internal derangements of the temporomandibular joint (TMJ) require a combination of radiograph procedures, including transcranial or pantographic x-rays, tomograms, arthrography and possibly CT. Magnetic resonance imaging (MRI) is an alternative technique for viewing the soft tissues of the joint without exposure to ionizing radiation. Preliminary MR scans of human TMJ's (1.5 Tesla, using 6 cm surface coils signal detectors) produced highly detailed images. However, accurate identification of small structures within the joint capsule, such as the sections of the meniscus, requires further study prior to clinical application. Because the MR image is based on signals which reflect complex characteristics of the tissues related to their physiology as well as structure, variations between individuals and between healthy and diseased structures may occur. Limited data is currently available relating MR signal strength and tissue characteristics. This project will investigate the potential use of MR to detect derangement of the TMJ soft tissues and to provide information regarding the degree of pathology in the meniscus and posterior ligament tissues. Anatomic relationships as shown in MR images of fresh cadaver TMJ's will be compared with gross morphology, dissection and histological evaluation. Further, the MR signal characteristics of fresh, surgically excised meniscal and posterior ligament tissue will be correlated with detailed histological assessment of these tissues using standard histological procedures and stereometric image analysis. Finally, MR scanning of a limited number of human subjects with and without intracapsular pathology will be performed to corroborate the results of the in vitro studies and determine the appropriateness of future studies of the clinical efficacy of MRI for evaluation of specific forms of temporomandibular joint dysfunction. Surgical verification and tissue samples will be obtained from 2/3 of the subjects. This investigation represents a collaboration between the Univ. of Penna. Schools of Medicine and Dental Medicine and the School of Dentistry at the S.U.N.Y. at Buffalo. The investigators at the Univ. of Penna. have extensive expertise and unique MR imaging facilities for magnetic resonance studies, while the investigators at S.U.N.Y. have sophisticated automated histology equipment and a large resource for TMJ patients.