Bias and allostery at the calcium sensing receptor

本项目旨在提供人类钙敏感受体（CaSR）的结构、功能和生理的机制和动态图像，这对脊椎动物的生命至关重要。通过对体内化学物质作出反应，它作为一种普遍的营养传感器，维持细胞外钙稳态并介导生物功能，包括神经传递、炎症、消化、血压和发育。然而，目前尚不清楚这种单一受体如何控制多种配体的作用来介导多种功能。通过阐明CaSR及其配体的作用，本项目旨在更好地了解基本的生理过程。

This project aims to provide a mechanistic and dynamic picture of the structure, function and physiology of the human calcium sensing receptor (CaSR), which is critical for vertebrate life. By responding to chemicals in the body, it acts as a universal nutrient sensor to maintain extracellular calcium homeostasis and mediate biological functions, including neurotransmission, inflammation, digestion, blood pressure and development. However, it is not known how this single receptor controls the actions of multiple ligands to mediate numerous functions. By elucidating the roles of the CaSR and its ligands, this project aims to better understand fundamental physiological processes.