ERG AND VEP AS INDICES OF PHOTOPIC DYSFUNCTION

儿童早期眼病的发现、治疗和预防 这在很大程度上取决于对机制的透彻理解 是人类视觉系统生长和发展的基础。这个 这项研究的具体目的是研究正常和异常的视觉 使用两种技术的婴幼儿系统，一种 电生理(视觉诱发电位-VEP)，其他， 心理物理(强迫选择优先观看--FPL)。第一，一系列 一系列实验被用来确定为什么“视觉诱发电位视力”更好 婴幼儿的“FPL视敏度”。这些实验 包括：1)使用两种方法对图形VEP进行单次试验分析 可选择的强迫选择心理物理程序；2)直接比较 使用反相方波栅的近视和视觉诱发电位敏感度； 光栅亮度、对比度和取向变化的影响 刺激对VEP和FPL视力阈值的影响。这项研究的第二个目标是 以确定使用图形VEP作为视力筛查是否可行 学龄前儿童的技术。为了实现这一目标，模式视觉诱发电位将 来自3个日托中心的1,250名学龄前儿童的记录。在……里面 除了视觉诱发电位，视力、立体视觉和运动能力也将 量过了。未通过任何测试的儿童将接受眼科检查 在我们的门诊眼科检查。的最终目标是 筛查研究将确定VEP是否可以用于筛查 婴儿和学步儿童。这项研究的第三个目标是直接 比较VEP和FPL技术的快速版本在检测和 单眼先天性白内障致弱视的治疗 婴幼儿斜视、屈光参差、上睑下垂和眼睑血管瘤 孩子们。为了最大限度地提高获得有用资源的可能性 来自每只眼睛的信息，只有相对的眼睛间敏锐度差异 将会被测量。单目视觉诱发电位将只记录一次检查 N1P1和P1N2VEP成分的眼间波幅比 并测量双眼P1潜伏期差值。Fpl 眼间视力评估将使用适当的年龄来获得。 阈值以上诊断条纹。

The detection, treatment and prevention of early childhood eye disease depends to a great extent on a thorough understanding of the mechanisms underlying the growth and development of the human visual system. The specific aims of this research are to study the normal and abnormal visual system of infants and young children using two techniques, one electrophysiological (the visual evoked potential - VEP), the other, psychophysical (forced-choice preferential looking - FPL). First, a series of experiments is proposed to determine why "VEP visual acuity" is better than "FPL visual acuity" in infants and young children. These experiments include: 1) a single trial analysis of the pattern VEP using a two alternative forced-choice psychophysical procedure; 2) a direct comparison of FPL and VEP acuity using counter-phase square wave gratings; and 3) the effect of changes in the luminance, contrast and orientation of grating stimuli on VEP and FPL acuity threshold. A second goal of this research is to determine if it is feasible to use the pattern VEP as a vision screening technique in pre-school children. To achieve this aim, pattern VEPs will be recorded from 1,250 preschool children at 3 day care centers. In addition to VEPs, visual acuity, stereopsis and motility will also be measured. Children who fail any of the tests will receive an ophthalmic examination in our out-patient eye service. The ultimate goal of the screening study will be to determine if the VEP can be used to screen infants and toddlers. The third goal of this research is to directly compare "fast" versions of VEP and FPL techniques in the detection and treatment of amblyopia caused by uniocular congenital cataracts, strabismus, anisometropia, ptosis and lid hemangiomas in infants and young children. In order to maximize the probability of obtaining useful information from each eye, only relative interocular acuity differences will be measured. Monocular VEPs will be recorded with only one check size; the interocular amplitude ratio for the N1P1 and P1N2 VEP components and the interocular P1 latency difference will be measured. FPL interocular acuity estimates will be obtained using age appropriate suprathreshold diagnostic stripes.