VISUAL SYSTEM ORGANIZATION AND DEVELOPMENT

这项研究的总体目标是了解平行路径是如何从 在灵长类动物中，视网膜到皮质的组织和发育。这项建议 代表了关于组织和成熟的研究的继续 X、Y和W类信息频道。概述的三个具体目标 将调查成虫的特征和出生后的成熟 这些小路中。在目标一中，建议进行研究以证实和扩展 了解人体内的基本生理和形态划分 成年Galagos从视网膜到纹状皮质的通路。感受野 将检查视网膜神经节细胞的特性，并将其与 外侧膝状核(LGN)内的细胞亚类 信息是如何转化的。视网膜神经节细胞的形态， LGN细胞及其传入细胞将被研究以区分 与生理相关的特征。类W型LGN细胞的变化 停用后，还将检查感受场属性 以确定顶盖神经元在此通路中的作用。AIM II将检查 在特定目标I中发现的特征的发展作为一种手段 更好地了解成人组织。研究概述了 将对LGN的成熟生理和形态进行研究。最后， AIM III将通过以下方式测试从Galago数据中得出的假设的应用 Galago与其他两种灵长类的比较研究 它们独特的视觉系统特征。在这些研究中，皮质 视觉诱发电位将被用来定义失活的效果 小细胞或大细胞LGN层在空间和 时间对比敏感度。 这些研究的结果不仅应该增加我们对 这些通道在视觉中的作用，也是对其 可能易受产后经历改变的影响。

The overall aim of the research is to understand how parallel pathways from retina to cortex are organized and developed in primates. The proposal represents a continuation of studies on the organization and maturation of X-, Y-, and W-like information channels. The three Specific Aims outlined will investigate the adult distinguishing features and postnatal maturation of these pathways. In Aim I, studies are proposed to confirm and expand knowledge of the basic physiologic and morphologic divisions within the pathways from retina to striate cortex in adult galagos. Receptive field properties of retinal ganglion cells will be examined and compared to those of cell subclasses within the lateral geniculate nucleus (LGN) to determine how information is transformed. The morphology of retinal ganglion cells, LGN cells, and their afferents will be investigated for distinguishing features that correlate with the physiology. Change in W-like LGN cell receptive field properties will also be examined following inactivation of tectal neurons to determine the role of this pathway. Aim II will examine the development of features uncovered in Specific Aim I as a means of better understanding the adult organization. Studies are outlined that will investigate the maturation of LGN physiology and morphology. Finally, Aim III will test the iplications of hypotheses derived from galago data by comparative studies on galago and two other primate species selected for their distinctive visual system chacteristics. In these studies, cortical visual evoked potentials will be used to define the effect of inactivation of either the parvocellular or magnocellular LGN layers on spatial and temporal contrast sensitivity. Results of these studies should not only add to our understanding of the roles of these channels in vision but also to knowledge about their potential vulnerability to altered postnatal experience.