ABERRATIONS OF EYES IN NORMAL AND CLINICAL POPULATIONS

描述：(改编自申请人的摘要。)评价表 正常和异常角膜的光学质量一直受到限制 主要是对视觉性能的测量，例如对比度 敏感度、敏锐度和眩光。虽然这些措施反映了以下方面 角膜的光学质量，它们不容易反映光学的变化 表现作为瞳孔大小的函数，也不给出具体的洞察力 各种光学改进或缺陷的原因。的具体目的 这项研究是为了开发快速、客观的角膜光学测量方法 质量，能够预测任何学生视觉表现的变化 兴趣的大小。这将通过计算 角膜单色波像差的最新研究进展 正常人和不同疾病患者的角膜地形图测量 扰乱正常角膜地形图的角膜状况。这些数据 将反过来被用来量化 高阶像差及其对光学传输的影响 正常人和受损眼的角膜功能(OTF) 角膜地形图；并预测由此导致的眼睛视力的变化 表现为瞳孔大小的函数。这项研究的最终目的 是确定改变的角膜地形图和 视觉功能减退，从而减轻 旨在改善眼睛图像质量的角膜疗法。

DESCRIPTION: (Adapted from applicant's abstract.) The evaluation of optical quality of the normal and abnormal cornea has been limited principally to measurements of visual performance such as contrast sensitivity, acuity and glare. While these measures reflect aspects of corneal optical quality, they do not readily reflect changes in optical performance as a function of pupil size, nor give insight to the specific cause of the various optical improvements or deficits. The specific aim of this research is to develop fast, objective measures of corneal optical quality, capable of predicting changes in visual performance for any pupil size of interest. This will be accomplished by calculating the monochromatic wave aberrations of the cornea from the state-of-the-art corneal topography measurements on normal eyes and patients having various corneal conditions which disrupt normal corneal topography. These data will in turn be used to quantify the amount and degree of variation in the higher order aberrations and their influence on the optical transfer function (OTF) of the cornea for normal eyes and eyes with disrupted corneal topography; and predict the resulting changes in the eye's visual performance as a function of pupil size. The ultimate goal of the research is to identify the relationship between altered corneal topography and diminished visual function, thus lessening the adverse consequences of corneal therapies designed to improve the image quality of the eye.