AGEing and NuTrition Sensing (AGENT)

虽然众所周知，年龄对新陈代谢有着深远的影响，但对于为什么有些人的新陈代谢速度比其他人快，却没有真实的理解。存在许多假说来解释营养和衰老如何影响新陈代谢从而影响衰老。对模式生物的研究表明，营养和用于感知营养环境的系统在衰老中发挥作用，并且已经确定了与更长寿命相关的几个基因和途径。建议的网络将集中于营养感知及其在衰老过程中所扮演的角色，我们的目标是解决“老年健康寿命和生活质量”的优先领域。为了解决目前的知识差距，并在营养感测和老化领域发展更深入的机械和转化理解，我们汇集了五所大学合作伙伴，即帝国理工学院伦敦，纽卡斯尔，布里斯托，曼彻斯特和爱丁堡，所有这些都在营养，营养感测和老化方面有良好的记录。虽然每个大学都有一个领先的CoI，但他们带来了许多专业和网络，这些专业和网络都是在营养传感和老化领域建立的。这给了我们一个高度多学科的网络，从基础细胞生物学到政策制定。该网络将使用黑客方法（我们在其他网络中成功使用的方法）来开发多学科研究主题，该网络将支持这些主题发展为全面的赠款申请并为科学文献做出贡献。该网络将有一个开放的政策，欢迎新成员加入网络。我们还将建立一个早期职业网络，以确保能力发展。由于该网络的一个主要目的是为研究应用开发新的想法，我们相信这将使该网络的生命远远超出资助期。

While it is known that age has a profound effect on metabolism, there is no real understanding about why some people metabolically age at a faster rate than others. A number of hypotheses exist to explain how nutrition and ageing impacts metabolism to effect ageing. Studies in model organisms have shown that nutrition and the systems used to sense the nutritional environment play a role in ageing and several genes and pathways have been identified that are associated with greater lifespan. The proposed network will focus on nutrient sensing and the role it plays in the ageing process, we aim to address the priority area of "healthspan and quality of life in old age". To address the current gaps in knowledge and to develop deeper mechanistic and translational understanding in the area of nutrient sensing and ageing, we have brought together five university partners that are Imperial College London, Newcastle, Bristol, Manchester and Edinburgh, all of which have a track record in either nutrition, nutrient sensing and ageing. Although each University has a lead CoI, they bring with them many specialities and networks based in their institution, which are both established and new to the area of nutrition sensing and ageing. This has given us a highly multidisciplinary start to the network that spans fundamental cell biology through to policy making. The network will use hackathon methodology (a methodology which we have used successfully in other networks) to develop multidisciplinary research topics which the network will support to develop into full grant application and contribute to the scientific literature. The network will have an open-door policy to welcoming new members into the network. We will also develop an early career network to ensure capacity development. As a major aim of the network is to develop new ideas for research application we believe that this will give the network life far outside of the funding period.