Developing multiscale models of digestion to enable targeted product solutions for nutrition and metabolic health

开发多尺度消化模型，为营养和代谢健康提供有针对性的产品解决方案

• 批准号: BB/P023851/1
• 负责人: Gary Frost
• 金额: $ 16.55万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FP023851%2F1
• 关键词: Developing; multiscale; models; digestion; enable

The gastrointestinal tract is a continuous organ with different complex environments along its length aimed at the efficient absorption of food. The impact that food can make, through an number of mechanisms, on appetite regulation and glucose homeostasis can occur in the gastrointestinal tract from the mouth to the colon. However, the greatest impact on satiety and glucose regulating hormones released from the gastrointestinal tract is seen after 30-60 minutes following the consumption of food. There is little understanding of the relationship between early food digestion and the metabolic processes that drive mechanisms that effect appetite and glucose homeostasis. Our aim is to develop multiscale models of digestion incorporating engineering and theoretical physics methodologies to enable targeted product solutions for nutrition and metabolic health. We will develop a fundamental understanding which provides a vital basis to understanding a range of scientific and technological questions outlined below:1. Rational design of dietary components to maintain a healthy weight is critically important to enable healthy ageing. In England, 60% of the adult population is overweight or obese, which imposes a major public health and financial burden. Therefore, it becomes a priority to understand how dietary components can maintain energy and glucose homeostasis across the lifespan. 2. On a global scale, rational design of foodstuffs is required to ensure enhanced calorie availability and the most efficient use of food resources that will be relevant to the developing world.3. Understanding of the healthy gut to inform models of diseases of the digestive system is needed.This is particularly timely because of recent advances in the new techniques that are becoming available (multi-scale modelling, physical imaging). We are also able to build on advances under the DRINC projects, which have contributed new understanding of the biochemical and biophysical digestive environment. The work also builds on the harmonised INFOGEST protocol from an EU-based project. In addition, as a result of the sandpit, we have identified novel expertise across disciplines which has a very obvious role to play in deciphering the complexities of digestion of food structures.

胃肠道是一个连续的器官，沿着它的长度沿着具有不同的复杂环境，目的是有效地吸收食物。食物通过多种机制对食欲调节和葡萄糖稳态的影响可以发生在从口腔到结肠的胃肠道中。然而，对饱腹感和胃肠道释放的葡萄糖调节激素的最大影响是在进食后30-60分钟。早期食物消化和代谢过程之间的关系，驱动机制，影响食欲和葡萄糖稳态的了解很少。我们的目标是开发多尺度消化模型，结合工程和理论物理方法，为营养和代谢健康提供有针对性的产品解决方案。我们将发展一个基本的理解，这为理解下面概述的一系列科学和技术问题提供了重要的基础：1。合理设计膳食成分以保持健康体重对健康老龄化至关重要。在英格兰，60%的成年人口超重或肥胖，这给公共卫生和财政带来了沉重的负担。因此，了解饮食成分如何在整个生命周期内维持能量和葡萄糖稳态成为当务之急。2.在全球范围内，需要合理设计食品，以确保增加卡路里供应，并最有效地利用与发展中国家有关的粮食资源。了解健康的肠道，以告知消化系统疾病的模型是必要的。这是特别及时的，因为最近的进展，新技术正在成为可用（多尺度建模，物理成像）。我们还能够在DRINC项目的基础上取得进展，这些项目对生物化学和生物物理消化环境有了新的认识。这项工作还建立在欧盟项目的协调INFOGEST协议的基础上。此外，由于沙坑，我们已经确定了跨学科的新专业知识，在破译食物结构消化的复杂性方面发挥了非常明显的作用。

项目成果

Development of computational design tools for characterising and modelling cutting in ultra soft solids

• DOI: 10.1016/j.eml.2020.100964
• 发表时间: 2020-10
• 期刊: Extreme Mechanics Letters
• 影响因子: 4.7
• 作者: C. Skamniotis;M. Charalambides

Modelling deformation and flow of food during oral and gastric processing

模拟口腔和胃加工过程中食物的变形和流动

• DOI: 10.1016/j.sctalk.2022.100069
• 发表时间: 2022
• 期刊: Science Talks
• 作者: Charalambides M

Handbook of Food Structure Development

食物结构发展手册

• DOI: 10.1039/9781788016155-00383
• 发表时间: 2019
• 作者: Dalkas G

Eulerian-Lagrangian finite element modelling of food flow-fracture in the stomach to engineer digestion

胃内食物流动断裂的欧拉-拉格朗日有限元建模以工程消化

• DOI: 10.1016/j.ifset.2020.102510
• 发表时间: 2020
• 期刊: Innovative Food Science & Emerging Technologies
• 影响因子: 6.6
• 作者: Skamniotis C

A study protocol for a randomised crossover study evaluating the effect of diets differing in carbohydrate quality on ileal content and appetite regulation in healthy humans.

• DOI: 10.12688/f1000research.17870.2
• 发表时间: 2019-01-01
• 期刊: F1000Research
• 作者: Byrne, Claire S;Blunt, Dominic;Frost, Gary
• 通讯作者: Frost, Gary