Defining the earliest events in lymphatic vasculature formation from veins

血管系统的发育是胚胎最早发生的事件之一。整个淋巴血管系统是由胚胎早期的静脉形成的。该项目旨在确定最早的分子和细胞变化，这些变化对于从胚胎中的几个前体细胞形成完整的第二血管网络至关重要。该项目旨在利用斑马鱼和老鼠胚胎来极大地扩展对这一重要脊椎动物组织形成的认识。最终，这有望为干细胞和前体细胞分化、复杂器官系统的进化和组织形成提供新的知识。结果可能影响未来生物技术领域的组织工程，干细胞分化和再生。

Vascular system development is one of the earliest events that occurs in the embryo. The entire lymphatic vascular system forms from the embryo’s early veins. This project aims to define the earliest molecular and cellular changes essential to form an entire second vessel network from just a few precursor cells in the embryo. The project aims to utilise zebrafish and mouse embryos to greatly expand knowledge in the formation of this essential vertebrate tissue. Ultimately, this is expected to provide new knowledge in stem and precursor cell differentiation, the evolution of complex organ systems and tissue formation. Outcomes may impact on future biotechnology in the areas of tissues engineering, stem cell differentiation and regeneration.