METALLOENZYME SITES--SYNTHESES AND BIOMIMETIC CHEMISTRY

金属蛋白杂氰菊酯的活性部位部分， 血蓝和天青的合成方法是通过将 适当数量的咪唑、硫醇和/或硫醚 基团到双环有机化合物使所有的金属 通过有机结构，连接基团被保持在相同的 它们在自然系统中占据的相对位置。这将是 通过各种金属催化的偶联反应完成， Diels-Alder反应和咪唑环的合成。新的 将为耦合和Diels开发综合方法学- 涉及咪唑和其他杂环的阿尔德反应。这个 合成位金属络合物的仿生行为 分子将通过快速动力学和各种光谱进行研究。 方法：研究方法。将这些合成过程应用于 含其他多种多咪唑类化合物的制备 还将探索活跃的地点。

The active site sections of the metalloproteins hemerythrin, hemocyanine, and azurine will be synthesized by attaching the appropriate numbers of imidazoles, thiol groups, and/or thioether groups to bicyclic organic compounds so that all the metal liganding groups are held, by the organic structure, in the same relative positions they occupy in natural systems. This will be accomplished by various metal-catalyzed coupling reactions, Diels-Alder reactions, and imidazole ring syntheses. New synthetic methodology will be developed for coupling and Diels- Alder reactions involving imidazoles and other heterocycles. The biomimetic behavior of the metal complexes of the synthetic site molecules will be studied by fast kinetic and various spectroscopic methods. The application of these synthetic procedures to the preparation of a variety of other multi-imidazoles containing active sites will also be explored.