Histone deacetylase functions in immune cells

该项目旨在确定酶（组蛋白脱乙酰酶）如何使先天免疫细胞（巨噬细胞）对特定的危险信号做出反应，例如激活Toll样受体的信号。为了确定提供特异性信号转导途径的过程，本项目将研究巨噬细胞中特定IIa类组蛋白脱乙酰酶的蛋白靶点和生物学功能。该项目预计将导致对免疫细胞反应中的组蛋白脱乙酰酶和蛋白质脱乙酰化的理解，这些酶和蛋白质脱乙酰化可用于操纵细胞功能，用于基础科学和生物技术用途。

This project aims to define how an enzyme (a histone deacetylase) enables innate immune cells (macrophages) to respond to specific danger signals, such as those activating Toll-like Receptors. To identify processes that provide specificity to signal transduction pathways, this project will characterise protein targets and biological functions of a specific class IIa histone deacetylase in macrophages. This project expects to result in an understanding of histone deacetylases and protein deacetylation in immune cell responses which can be harnessed to manipulate cell functions for basic science and biotechnology uses.