Mass Spectrometry to Support Synthetic Chemistry in Durham

质谱法是测定化学成分和结构的基本分析技术，根据所采用的精确方法，不仅可以用于分析离散的分子种类，还可以用于分析非共价相互作用在结构稳定性中起突出作用的较大结构（即多个片段通过除化学键以外的力相互作用的系统）。本申请中要求的新设备将用于研究项目，旨在发现增强生物成像所必需的新分子报告，下一代电子设备的功能分子，以及包括催化在内的新合成方法。达勒姆大学化学系是英国领先的研究部门之一，长期以来一直享有卓越的声誉。该系的研究由大约40名学者领导，涉及化学科学与工程学、物理学和生物学的边界。在这个多样化的研究空间中，可以确定共同的新需求和资源。在新仪器上的投资可以被多个研究小组使用，追求不同的科学目标，除了帮助维护英国的研究基础设施外，还提供了最大的价值。这一请求属于这一类，它寻求资助，用新的更多功能的仪器取代旧的和老化的质谱仪，这将支持该部更大比例的研究小组发展新的研究方向。

Mass spectrometry is an essential analytical technique in the determination of chemical composition and structure and depending upon the precise method employed, can be used in the analysis of not only discrete molecular species, but also larger structures in which non-covalent interactions play a prominant role in structural stability (i.e. systems in which multiple fragments interact through forces other than chemical bonds ). The new equipment requested in this application will be used in research projects directed towards the discovery of new molecular reporters that are necessary for enhanced bioimaging, functional molecules for the next generation of electronic devices, and new methods of synthesis, including catalysis.The Chemistry Department at Durham is one of the leading research Departments in the UK, with a long-standing reputation for excellence. The Department's research, which is led by some 40 academics, touches the boundaries of the chemical sciences with engineering, physics and biology. Across this diverse research space, common new needs and resources can be identified. Investment in new instrumentation that can be used by multiple research groups, pursuing a diverse range of scientific goals, provides maximum value for money in addition to helping maintain the UK research infrastructure. This request falls into this category seeking funding to replace old and ageing mass spectrometers with new more versatile instruments that will support a greater proportion of the research groups in the Department in developing new lines of research.