EFFECTS OF ULTRASONIC RADIATION ON FETAL GONADS

这项研究的目的是确定其程度和性质 可以产生的形态效果，由低 兆赫兹超声波，对胎儿性腺发育的影响。AS 超声在临床上得到了广泛的应用，无论是在诊断上还是在 治疗内脏器官有机会接受 大量暴露。尽管有害的生物效应 在临床诊断使用后没有报道，也没有 可以毫不含糊地说，生物效应 不能进行超声波检查。这是一个相当大的患者 暴露发生在对妊娠子宫的检查中。是这样的 诊断性超声波暴露现在涉及数百万人 人，美国近一半的孕妇 目前正在为产科目的而扫描的国家，因此 我们未来人口的很大一部分将会是 出生前暴露于超声波的。虽然对 胎儿还没有报道，细微的影响还没有报道 学习。本研究的目的是询问是否 低水平会影响胎儿性腺发育 超音波。初步研究表明，1兆赫的超声波 10W/cm2照射10秒对胎儿性腺有影响。这个 拟议的研究将涉及确定达到以下标准的阈值 胎鼠的性腺会发生结构变化。跟随 确定结构变化的超声阈值 发生在胎鼠性腺上。在确定了 发生不可逆效应的超声阈值，光 并对胎儿性腺的电子显微镜进行研究。这个 这项研究的结果将为评估发生的风险提供依据 对胎儿性腺结构的影响 治疗和诊断程序。

It is the purpose of this study to determine the degree and nature of the morphological effects that could be produced, by low megaherz ultrasound, to fetal gonadal development. As ultrasound is widely used clinically, both in diagnosis and in therapy visceral organs have the opportunity to receive substantial exposure. Although deleterious biological effects have not been reported following clinical diagnostic usage, it is also not possible to state, unequivocally, that biological effects of ultrasound cannot occur. An area in which considerable patient exposure occurs is in the examination of the gravid uterus. Such diagnostic ultrasound exposures have now involved millions of people, with nearly half of all pregnant women in the United States now being scanned for obstetric purposes, such that a significant fraction of our future population will have been exposed to ultrasound prior to birth. Although effects to the fetus have not been reported, subtle effects have not been studied. It is the purpose of the present study to inquire whether fetal gonadal development can be affected by low level ultrasound. A preliminary study showed that 1 MHz ultrasound exposures at 10 W/cm2 for 10 sec affected fetal gonads. The proposed study will involve determining thresholds at which structural changes occur to fetal murine gonads. Following identification of ultrasound thresholds at which structural changes occur to fetal murine gonads. Following identification of ultrasound thresholds at which irreversible effects occur, light and electron microscopy of fetal gonads will be investigated. The results of this study will provide a basis for assessing risk incurred by fetal gonadal structures during exposure to ultrasound at both therapeutic and diagnostic procedures.