POLYMER NANOMEDICINE: ENHANCING THE TRANSLATION FROM THE LAB TO THE CLINIC

有必要加快生物医学应用配方的设计、优化和评价过程。当涉及到可以跨越不同屏障、仅针对受损部位的治疗剂的工程新型纳米颗粒时，这样的过程更加关键。今天，这种统称为纳米医学的努力正在彻底改变传统疗法，并使全新的治疗和诊断方法成为可能。纳米医学是一门涉及物理学家、化学家、工程师、生物学家和临床医生的多方面学科。这种跨学科的性质可能同时是纳米医学最大的优势和最大的弱点。事实上，虽然这可以更全面地了解不同的物理化学方面以及生物学方面的影响，但不同学科的方法和途径往往有很大不同，阻碍了最终结果的验证和快速转化。在这里，我们提出了一种严格的方法来合成和临床前评估许多纳米颗粒用于输送热疗遗传物质。将对这些进行筛选，开发并采用适用于纳米颗粒的最先进的生物学评估。我们计划筛选数以千计的配方，目标是找出对癌症治疗和运动神经元退行性疾病都有巨大影响的少数配方。

There is a necessity to speed up the process of design, optimization and evaluation of formulation for biomedical applications. Such a process is even more crucial when it comes to the engineering novel nanometer-sized particles that can deliver therapeutic agents across the different barrier targeting only the damaged sites. Today such effort collectively known as Nanomedicine, is revolutionizing traditional therapy and enabling completely new therapeutic and diagnostic approaches. Nanomedicine is a multifaceted discipline that involves physicists, chemists, engineers, biologists and clinicians. This interdisciplinary nature is possibly nanomedicine greatest strength and greatest weakness at the same time. Indeed while this allows a more complete understanding of the different physico-chemical aspects as well as the biological implications, often the methodologies and the approaches are substantially different across the different disciplines hindering the validation and the fast translation of the final results. Herein we propose a rigorous approach of synthesis and pre-clincial evaluation of many nanoparticles for the delivery of theraupetic genetic materials. These will be screened developing and employing state-of-the-art biological evaluations adapted for nanoparticles. We plan to screen for thousands of formulation and aiming to identify few that will have a tremendous impact in both cancer therapy and motoneuron-degenerative disorders.