TRIAL OF PIRACETAM IN DYSLEXIC SUBTYPES

该项目的主要目的是评估（1）是否患有诵读困难症 孩子们在参加课外辅导时， 促智药吡拉西坦和（2）是否诵读困难归类为 发声困难患者从联合干预中获益大于 那些因其他原因导致阅读障碍的人。 在三个夏天（1987年，1988年，1989年），60精心挑选 年龄在9到13岁之间的儿童将参加这项研究， (20/summer）。 符合入选标准的每名儿童的父母 将有机会让他们的孩子参加一个免费的10- 一周的辅导计划，只要他们同意让孩子 在研究期间盲法分配至活性药物或安慰剂组 10-周期间。 一半的阅读障碍者将符合以下标准 分类为发音困难;其他30个将不符合这些 的搜索. 每组中的一半将被随机分配 活性药物或安慰剂的情况。 所有参与者将 与一位阅读专家（导师）会面，进行两次私人的小时课程 的一年 导师不会知道哪些孩子在接受 活性药物（父母或研究者也不会），她将 不知道调查人员是否将孩子归类为 有没有发音障碍 每一次辅导课程的结构将是 包括20分钟直接语音训练（如Lynette所述 布拉德利，1984年），20分钟的练习，在阅读，和20 几分钟的拼写单词写作指导。 在接受进入该项目之前， 通过一系列测试来提供基线数据， 两个诵读困难的亚组。 吡拉西坦将在 每毫升含有0.33克吡拉西坦的糖浆。 孩子会 在早餐前给予5毫升糖浆， 在晚餐前的晚上。 安慰剂将以相同剂量给药 时尚. 孩子们会被告知糖浆可以帮助他们 学习更容易。 在为期10周的试验结束时（ 药物治疗），孩子们将重新进行阅读测试 从筛选电池。

The major aims of this project are to assess (1) whether dyslexic children show increased benefit from tutoring when taking the nootropic drug piracetam and (2) whether dyslexics classified as dysphonetic benefit more from the combined intervention than those whose dyslexia stems from other causes. Over three summers (1987, 1988, 1989), 60 carefully chosen dyslexic children aged 9 to 13, will participate in the study (20/summer). The parents of each child meeting inclusion criteria will be given the opportunity to enroll their child in a free 10- week tutoring program provided they will agree to have the child blindly assigned to an active drug or placebo condition during the 10-week period. Half the dyslexic subjects will meet criteria for classification as dysphonetic; the other 30 will not meet these criteria. Half in each of these groups will be randomly allocated to the active drug or placebo condition. All participants will meet a reading specialist (tutor) for two private hourly sessions per week. The tutor will not know which children are receiving the active drug (nor will the parents or investigators), and she will not know whether the investigators have classified the child as dysphonetic or not. Each tutoring session will be structured to include 20 minutes of direct phonetic drill (as outlined by Lynette Bradley, 1984), 20 minutes of practice at reading aloud, and 20 minutes of spelling - word writing instruction. Prior to acceptance into the project the children will be screened with a battery of test to provide baseline data and to assign them to the two dyslexic subgroups. Piracetam will be administered in a syrup containing 0.33 g of piracetam per ml. The child will be given 5 ml of the syrup in the morning before breakfast and 5 ml in the evening before dinner. Placebo will be given in identical fashion. The children will be told the syrup may help them to learn more easily. At the end of the 10 week trial (and while still on medication), the children will be retested on the reading tests from the screening battery.