Metal-free Arylations for Green Chemistry

有机化学主要研究分子的合成。为了高效的合成，我们必须对原子之间的键形成或断开的方式以及分子之间如何相互反应有合理的了解。在这个提议中，我们利用了一类含有碘原子的有趣分子的特殊性质。我们建议合成新的试剂，并研究仅在催化量下使用这些试剂的反应。这意味着一个催化剂分子将有可能产生数千个具有特殊性质的新分子。这些新碘试剂的发展及其在各种反应中的应用，允许芳香部分的选择性转移，构成了本提案的主要部分。在这些反应中获得的目标结构存在于天然产物和许多药物中。因此，对这些化合物的快速和无金属接触将使它们能够快速合成并促进新的生物活性分子的开发。

Organic Chemistry is mainly dealing with the synthesis of molecules. For efficient synthesis, we must have reasonable insight into the way in which bonds between atoms can be formed or broken and how molecules can react with each other. In this proposal we make use of the special properties of an interesting class of molecules containing iodine atoms. We propose to synthesise novel reagents and investigate reactions using these reagents in only catalytic amounts. This means that one catalyst molecule will have the potential to create thousands of new molecules with special properties. The development of these new iodine reagents and their application in various reactions allowing the selective transfer of aromatic moieties form the main part of this proposal. The target structures which are obtained in these reactions are found in natural products and in many pharmaceuticals. A fast and metal-free access to such compounds will therefore enable their fast synthetic access and enhance the development of new bioactive molecules.