TRIAL OF PIRACETAM IN DYSLEXIC SUBTYPES

本项目的主要目的是评估(1)是否存在阅读障碍 孩子们从辅导中获得的好处在参加 促性激素药物吡拉西坦和(2)阅读障碍是否被归类为 发音困难患者从联合干预中受益更多 那些阅读障碍源于其他原因的人。 三个夏天(1987,1988,1989)，精心挑选了60个 9至13岁的阅读障碍儿童将参与这项研究 (20个/夏季)。符合纳入标准的每个孩子的父母 将有机会让他们的孩子参加免费的10- 每周辅导计划，前提是他们同意生下孩子 在治疗期间被盲目分配到活性药物或安慰剂状态 10周的时间。一半的阅读障碍受试者将符合 分类为发音困难；其他30个将不符合这些要求 标准。每组中的一半将被随机分配 处于活性药物或安慰剂状态。所有参与者将 与阅读专家(导师)会面，每小时进行两次私人会议 每周。家教不会知道哪些孩子收到了 活性药物(父母或调查人员也不会)，她会 不知道调查人员是否将孩子归类为 不管是不是发音困难。每一次辅导课程将被安排为 包括20分钟直接语音练习(如Lynette所述 Bradley，1984)，20分钟的朗读练习，20分钟 几分钟的拼写单词写作指导。 在接受该项目之前，将对儿童进行筛查 通过一组测试来提供基准数据并分配给它们 这两个阅读障碍亚群。吡拉西坦将在#年使用 一种每毫升含有0.33克脑复康的糖浆。 早餐前服用5毫升糖浆，早餐前服用5毫升 在晚餐前的晚上。安慰剂将以相同的方式给予 时尚。孩子们会被告知糖浆可能会帮助他们 学习起来更容易。在10周的试验结束时(虽然仍然 在药物治疗方面)，孩子们将在阅读测试中重新测试 来自筛查电池的。

The major aims of this project are to assess (1) whether dyslexic children show increased benefit from tutoring when taking the nootropic drug piracetam and (2) whether dyslexics classified as dysphonetic benefit more from the combined intervention than those whose dyslexia stems from other causes. Over three summers (1987, 1988, 1989), 60 carefully chosen dyslexic children aged 9 to 13, will participate in the study (20/summer). The parents of each child meeting inclusion criteria will be given the opportunity to enroll their child in a free 10- week tutoring program provided they will agree to have the child blindly assigned to an active drug or placebo condition during the 10-week period. Half the dyslexic subjects will meet criteria for classification as dysphonetic; the other 30 will not meet these criteria. Half in each of these groups will be randomly allocated to the active drug or placebo condition. All participants will meet a reading specialist (tutor) for two private hourly sessions per week. The tutor will not know which children are receiving the active drug (nor will the parents or investigators), and she will not know whether the investigators have classified the child as dysphonetic or not. Each tutoring session will be structured to include 20 minutes of direct phonetic drill (as outlined by Lynette Bradley, 1984), 20 minutes of practice at reading aloud, and 20 minutes of spelling - word writing instruction. Prior to acceptance into the project the children will be screened with a battery of test to provide baseline data and to assign them to the two dyslexic subgroups. Piracetam will be administered in a syrup containing 0.33 g of piracetam per ml. The child will be given 5 ml of the syrup in the morning before breakfast and 5 ml in the evening before dinner. Placebo will be given in identical fashion. The children will be told the syrup may help them to learn more easily. At the end of the 10 week trial (and while still on medication), the children will be retested on the reading tests from the screening battery.