COMPARATIVE NEUROPHYSIOLOGY

长期目标是提供关于人脑的观点以及如何 就神经活动整合的机制而言，它是进化的 中枢神经系统中神经元的有组织的组装，包括 宏电路和本地电路。其具体目的是使用比较级 用低等脊椎动物模型系统检查选定神经的方法 成就或结构，特别是包括感觉处理， 编码、解码、过滤、并行信息通道、交互 在不同级别的模式和有用信号的提取之间，从 第一个订单是大脑。八腹肌感觉系统(第八位 神经和侧线)以及小脑和高级中枢接受其 模式是一个特别的关注点。受体与脑结构分析 声学、振动、重力、加速度、水运动和微弱 电场刺激，对棘鳃、硬骨鱼和 其他脊椎动物将成为材料。他们将被研究与 其次，主要是生理学方法，但部分是解剖学方法。(I) 使用单电极从单个单元和多个单元记录 多个电极的阵列。(2)从细胞群体记录为 正在进行的和诱发的活动的细胞外场，用计算机 直方图、交叉关联、平均活动、功率的显示 光谱、相干性、带通滤波活动的包络、光谱和 不同波段和其他波段包络的互相关 可能区分更低级别和更高级别的描述符 组织。(Iii)注射过氧化物酶、钴、荧光染料或 放射性氨基酸及其部位的组织化学可视化 损伤。这个项目通常会占用2名学生，3名博士后 访客、私家侦探、一名工程师、技术员和秘书。续 与前访问科学家的合作以及新的合作 与本地和远程同事的联系也在计划之中。

The long term objectives are to give perspective on the human brain and how it evolved, in respect to mechanisms of integration of neural activity in organized assemblies of neurons in the central nervous system, including macro- and local circuits. The specific aims are to use the comparative approach with model systems in lower vertebrates to examine selected neural achievements or structures, including in particular sensory processing, encoding, decoding, filtering, parallel information channels, interactions among modalities and extraction of useful signals at various levels, from first order to cerebral. The octavolateralis system of senses (eighth nerve and lateral line) and the cerebellum and higher centers receiving its modalities are a special focus. Receptors and brain structures analyzing acoustic, vibratory, gravity, acceleration, water movement and weak electric field stimuli, in favorable species of elasmobranchs, teleosts and other vertebrates will be the materials. They will be studied with the following, mainly physiological but partly anatomical methods. (i) Recording from single units and multiple units with single electrodes and arrays of multiple electrodes. (ii) Recording from populations of cells as extracellular fields of ongoing as well as evoked activity, with computer displays of histograms, cross correlations, averaged activity, power spectra, coherence, envelopes of bandpass filtered activity, spectra and cross correlations of the envelopes of different bands and other descriptors that might distinguish lower and higher levels of organization. (iii) Injection of peroxidase, cobalt, fluorescent dyes or radioactive amino acids and histochemical visualization of sites of lesions. This project will normally occupy 2 students, 3 postdoctoral visitors, the P.I., an engineer, technician and secretary. Continued collaboration with former visiting scientists as well as new collaboration with local and distant colleagues are planned.