The hidden secondary metabolite biosynthetic potential of fungi

这项提议旨在开发合成生物学工具，使人们能够快速获得真菌基因组中编码的隐藏代谢物，并发现它们如何与植物和动物宿主相互作用。基因组测序显示，真菌蕴藏着巨大的潜在生物合成生物活性小分子。缺乏有效利用这种隐藏潜力的工具，阻碍了为制药学和农业开发这种未知的化学多样性并了解它们在病原体中的生物学作用的能力。预期结果包括生物活性分子的来源以及更好地管理作物和人类的真菌疾病。

This proposal aims to develop synthetic biology tools to allow rapid access to the hidden metabolites encoded in fungal genomes and discover how they interact with plant and animal hosts. Genome sequencing reveals that fungi harbour vast hidden potential for biosynthesis of bioactive small molecules. The lack of tools to efficiently access this hidden potential has hindered the ability to develop this uncharted chemical diversity for pharmaceutics and agriculture, and understand their biological roles in pathogens. Expected outcomes include sources of bioactive molecules and better management of fungal diseases in crops and humans.