MEG MEASUREMENT IN EPILEPSY

由于神经磁场的一些独特性质， 脑磁图（MEG）有望成为一种有价值的工具， 对人类和动物癫痫现象的非侵入性研究。 神经磁测量最近已被应用于实际的 癫痫灶在脑三维空间中的定位 局灶性癫痫发作患者。 然而，MEG测量的能力 细胞内电流，并记录快速和非常缓慢的变化 这些电流，使MEG不仅是一个实用的定位工具， 非侵入性研究癫痫细胞机制的方法。 到 认识到这一潜力，我们建议在研究青霉素癫痫的 大鼠 提出了三个初步实验，以建立一个经验 癫痫中神经磁场神经发生的基础。 在 这些研究表明，磁场强度与 癫痫灶的大小，磁场和细胞的方向 在重点，和可能的贡献，二手来源将是 考察 第四个实验考察了磁场与 场模式和已知的细胞内电流产生的直接皮层 刺激，用于与青霉素癫痫的领域进行比较。 的 其余的实验利用这些经验数据来探索 发作间期峰电流，快速发作峰电流，慢峰电流 发作时的电场变化和可能的发作间期的驻波场 这项工作 将介绍一个全新的生物磁学领域，动物磁力测量。 神经磁场神经发生的经验基础 在这项工作中建立将证实所有的解释 神经磁学领域的研究。 探索性研究 磁场的青霉素癫痫将作为一个必要的开始 未来的神经磁研究的细胞机制的点 癫痫 最后，本文还介绍了对长江中下游地区缓流场和驻波场的研究情况。 大鼠可能引入一种定位和研究癫痫发作的强大新方法 局灶性癫痫患者的病灶。

Because of a number of unique properties of neuromagnetic fields, magnetoencephalography (MEG) promises to be a valuable tool for the non-invasive study of epileptic phenomena in man and animals. Neuromagnetic measures have recently been applied to the practical localization of epileptic foci in the three dimensional cranial space of patients with focal seizure disorders. Yet, the capacity of MEG to measure intracellular currents, and to record both rapid and extremely slow changes of these currents, make MEG not just a practical localization tool but a means of noninvasively studying the cellular mechanisms of epilepsy. To realize this potential, we propose to study penicillin epilepsy in the rat. Three initial experiments are proposed to establish an empirical foundation for the neurogenesis of neuromagnetic fields in epilepsy. In these studies, the relationship between magnetic field strength and the size of the epileptic focus, the orientation of magnetic fields and cells within the focus, and possible contributions of secondary sources will be examined. The fourth experiment examines the relationship between magnetic field patterns and known intracellular currents produced by direct cortical stimulation, for comparison to the fields of penicillin epilepsy. The remaining experiments draw upon this empirical data to explore the intracellular currents of interictal spiking, rapid seizure spiking, slow ictal field shifts, and possible interictal standing fields. This work will introduce an entirely new area of biomagnetism, animal magnetometry. The empirical foundation for the neurogenesis of neuromagnetic fields established in this work will substantiate the interpretation of all studies in the growing field of neuromagnetism. Exploratory studies in the magnetic fields of penicillin epilepsy will serve as a necessary starting point for future neuromagnetic studies of the cellular mechanisms of epilepsy. Finally, the investigation of slow and standing fields in the rat may introduce a powerful new method of localizing and studying seizure foci in patients with focal seizure disorders.