Core Capability for Chemistry Research in Southampton

该申请的总体目标是现代化和增强南安普顿化学核心多用户仪器的能力，以确保EPSRC优先领域中化学和相关学科的广泛当前和未来研究项目的基础。设计、合成和表征分子物种的能力是化学的核心。核磁共振（NMR）光谱和质谱（MS）是有机和无机化学中广泛使用的两种关键技术，用于表征小分子和大分子和组件，以及鉴定复杂混合物中存在的单个成分。它们是非常强大的技术，大多数在这些学科工作的研究人员每天都在使用它们。该应用程序的关键要素包括：(i)用新的，更先进的仪器替换两个核磁共振光谱仪，以增加南安普顿核心开放获取核磁共振提供的容量，能力和弹性；（ii）用新的仪器取代旧的质谱系统，这将提供快速的通量，提高结果的质量，并允许对不适合核磁共振光谱的化合物进行结构解析。新质谱系统的高灵敏度也将有助于识别非常低水平但潜在重要的杂质，例如在医学成像中使用的放射性示踪剂的衰变过程中形成的杂质。扫描电子显微镜（SEM）是材料科学中一项重要的分析技术，它可以提供固体形态的高度放大图像，包括粉末、微晶体、薄膜和纳米颗粒。通过使用附着在扫描电镜上的特定探针，可以获得有关存在元素的定量信息，包括可能损害材料性能的低水平杂质。该申请还寻求通过更换其工作站和操作系统来升级现有的SEM仪器，并将确保将来能够从南安普顿化学公司生产的新材料中获得这些类型的信息。南安普顿化学致力于从资助下提供的资本设备中获得最大价值，并有机制使外部用户，包括公司和学者，使用这些设施来支持他们的研究活动。

The overall aim of this application is to modernise and enhance capability of core multi-user instrumentation in Southampton Chemistry to secure the underpinning of a wide range of current and future research projects in Chemistry, and associated disciplines, in EPSRC priority areas. The ability to design, synthesis and characterise molecular species lies at the heart of chemistry. Nuclear Magnetic Resonance (NMR) spectroscopy and Mass Spectrometry (MS) are two of the key techniques used very widely across organic and inorganic chemistry for the characterisation of small and large molecules and assemblies, and for the identification of the individual constituents present in complex mixtures. They are very powerful techniques that are used on a daily basis by most researchers working in these disciplines. Key elements of this application include: (i) replacing two NMR spectrometers with new, superior instruments to give increased capacity, capability and resilience to the core open access NMR provision at Southampton; (ii) replacing old MS systems with new instruments that will give fast throughput, improved quality results, and allow structural elucidation of compounds unsuitable for NMR spectroscopy. The very high sensitivity of the new MS systems will also be really beneficial for identification of very low level but potentially important impurities, for example those formed during the decay of radio-tracer species used in medical imaging.Scanning Electronic Microscopy (SEM) is an important analytical technique in materials science, which gives highly magnified images of the morphology of solids, including powders, microcrystals, thin films and nanoparticles. By using specific probes attached to the SEM, quantitative information concerning the elements present, including low level impurities that might compromise the properties of the materials, can be obtained. This application also seeks to upgrade an existing SEM instrument through replacement of its work station and operating system, and will ensure that the ability to obtain these types of information from new materials produced in Southampton Chemistry is maintained in the future.Southampton Chemistry are committed to obtain maximum value from the capital equipment provided under the grant and have mechanisms enabling external user, including companies and academics, to use the facilities to support their research activities.