WORKSHOP ON THE GENOME OF E COLI

所有基因组测序项目面临的两个主要问题是协调 测序工作的结果，并使序列可供 科学界。大肠杆菌测序项目也不例外， 提议将致力于对当前和未来的讨论 对大肠杆菌基因组进行测序的努力。这次会议的目的是 推进测序项目本身，整合测序 与更广泛的大肠杆菌遗传学家社区的研究项目。 这将通过将专业的参与者聚集在一起来完成 进行测序的实验室，其他实验室测序 较小的选定区域、维护DNA数据库的实验室 关于大肠杆菌的序列和其他信息，以及大肠杆菌遗传学家。在……里面 此外，对这些一般问题感兴趣的计算机专家将是 参与者。企业的国际化范围要求 来自欧洲和日本的科学家参加。 将讨论的议题将包括对以下方面的现状的审查 科学发现的测序工作和重点；是否 标准化是必要的，还是仅仅是可取的；如何进行排序 协调以避免过多的冗余，但确保准确性；数据库 数据录入、更正和访问的问题；大肠杆菌的整合 与大肠杆菌研究社区一起进行测序项目，以便 遗传、生理和序列数据可以相互关联、交叉检查 并被利用。 将在会议上进行的正式和非正式讨论 将导致各方更加凝聚和协调一致的努力，并将 成为未来进步的基础。

Two major problems facing all genome sequencing projects are coordination of the sequencing effort and making the sequence available for use by the scientific community. The E. coli sequencing projects are no exception and the proposed will be devoted to a discussion of the current and future efforts to sequence the genome of E. coli. The purpose of the meeting is to advance the sequencing project itself, and to integrate the sequencing project with the research of the broader community of E. coli geneticists. This will be done by bringing together participants fran the major laboratories performing the sequencing, other laboratories sequencing smaller selected regions, laboratories maintaining databases of DNA sequences and other information on E. coli, and E. coli geneticists. In addition computer experts interested in these general problems will be participants. The international scope of the enterprise requires participation by scientists from Europe and Japan. The topics to be discussed will include a review of the present status of the sequencing effort and highlights of the scientific findings; whether standardization is essential or merely desirable; how sequencing can be coordinated to avoid excessive redundancy but to ensure accuracy; database problems of data entry, correction and access; integration of the E. coli sequencing projects with the E. coli research community so that the genetic, physiological and sequence data can be correlated, crosschecked and used. The formal and informal discussions that will take place at the meeting will lead to a more cohesive and concerted effort by all parties, and will be the basis for future progress.