FASEB SUMMER RESEARCH CONFERENCE: CELL/MOLECULAR BIOLOGY

这是一份部分资金申请，以支持一年中的第四次 FASEB夏季生物研究会议系列会议 胃肠道(GI)。这些会议已经举行了 每两年举办一次，非常成功。科学关注的焦点 每次会议都有所不同；然而，一个不变的目标是 遗骸将老牌调查人员与年轻的 科学家和实习生将就美国退伍军人的前沿话题进行讨论 研究。拟议中的会议的另一个目标是引起人们的注意 GI调查人员对来自 相关的纪律，否则他们可能不会接触到。这个 会议将在铜山的非正式环境中举行 科罗拉多州的滑雪胜地，利用经济的淡季价格， 这使得年轻的和成熟的科学家都有可能 参加的时候至少要有经济援助。令人愉快的环境也 促进参与者之间的互动，以便提出想法 在正式会议期间，将在社会活动期间进行。这个 这次会议的必要性，以及它的主题，胃肠道 四：发展和修复--就细胞和分子方面达成一致 最后参与者以压倒性多数投了赞成票 在铜业举行的上一次会议(胃肠道III) 1989年7月的山上。福克斯受到了热烈的欢迎，因为 令人振奋并引导到现代研究的前沿 菲尔德。这是所有人都感兴趣的，要么是因为它与他们的 自己目前正在进行的工作，或者因为它具有教育价值 他们希望在未来进行的研究。实现了额外的好处 上一次会议应该在下一次会议中更加明显， 参加的细胞和分子生物学家从他们的接触中获得的 与GI科学家一起欣赏和洞察 决定整体更高水平行为的监管职能 管风琴。因此，对临床来说，这两个方面都有优势 胃肠病学和基础研究。目标将在以下方面实现 部分，通过举行以下会议：(1)干细胞和发育(更新 上皮)；(2)肠道的细胞和区域特异性调节 上皮基因表达；(3)上皮分化模型； (4)极化上皮细胞功能的发展和维持； (5)粘膜免疫中的内吞和跨细胞作用；(6)细胞外 胃肠道细胞分化的调控；(7)细胞迁移 和修复上皮；(8)神经脊和胃肠道 发展；(9)肠道炎症/过敏反应和神经 功能。几次会议将补充讨论者，谁将 对演讲者的陈述和谁将做好准备提前发出警告 开始讨论并介绍其有争议的方面 主题。年轻调查人员的海报摘要和非正式 在集体用餐、午休和社交期间的谈话 晚间会议将有助于最大限度地增加 参与者。

This is an application for partial funding to support the fourth in a series of FASEB summer research conferences on the biology of the gastrointestinal (GI) tract. These conferences have been held biannually have been remarkably successful. The scientific focus of each meeting has differed; however, a constant objective has been and remains to bring established investigators together with young scientists and trainees to confer on topics at the frontiers of GI research. Another goal of the proposed meeting is to draw the attention of GI investigators to relevant insights derived from research in related disciplines to which they might not otherwise be exposed. The meeting will be held in the informal surroundings of the Copper Mountain ski resort in Colorado, taking advantage of economical off-season rates, which make it possible for both young and established scientists to attend with a minimum of financial aid. The pleasant setting also facilitates interactions between participants, so that ideas raised during formal sessions will be pursued during social activities. The need for this conference, as well as its topic, Gastrointestinal Tract IV: Development and Repair-Cellular and Molecular Aspects were agreed upon by an overwhelmingly positive vote of the participants at the end of the previous conference (Gastrointestinal Tract III) at Copper Mountain in July, 1989. The focus was enthusiastically greeted as exciting and directed to the advancing front of modern research in the field. It was of interest to all, either because it related to their own current work in progress or because it was of educational value for research they wished to do in the future. An added benefit, realized in the previous conference that should be even more evident in the next, is that attending cellular and molecular biologists gain from their contact with GI scientists an appreciation and insight into the integration and regulatory functions that determine higher levels of behavior of a whole organ. Funamental advantages thus accrue both for clinical gastroenterology and basic research. Objectives will be achieved, in part, by holding sessions on: (1) Stem Cells and Development (Renewal of Epithelium); (2) Cell and Region-Specific Regulation of Intestinal Epithelial Gene Expression; (3) Models of Epithelial Differentiation; (4) Development and Maintenance of Polarized Epithelial Cell Function; (5) Endocytosis and Transcytosis in Mucosal Immunity; (6) Extracellular Modulation of Gastrointestinal Cell Differentiation; (7) Cell Migration and Repair of the Epithelium; (8) The Neural Crest and Gastrointestinal Development; (9) Intestinal Inflammation/Anaphylaxis and Neural Function. Several sessions will be supplemented discussants, who will be forewarned about the speakers presentations and who will be prepared to begin discussion and to introduce controversial aspects of their topics. Poster summaries by young investigators and informal conversations during group dining, afternoon recesses, and socialization after evening sessions will contribute to maximizing interactions among participants.