EPIDEMIOLOGY OF SALIVARY GLAND CANCER

将进行一项基于人群的病例对照流行病学研究， 调查与唾液腺发病率相关的危险因素 癌 10月至12月诊断的唾液腺癌病例 1990年1月1日和1993年12月31日，将通过快速病例确定 在两个联合国机构的主持下建立的查明制度， 加州肿瘤登记中心区域登记中心。 案件，谁来编号 大约285，将与选择的相同数量的对照进行比较 从一般人群中随机抽取， 五岁年龄组的基础。 将确定20-64岁的对照组 通过随机数字拨号过程。 65-79岁的对照组将 通过卫生保健财务管理局的记录确定。 电话访谈将使用结构化问卷进行 由受过训练的面试官进行面试。 问卷将包括 包括外源性暴露、病史和选定饮食的项目，k 生活方式和社会人口因素。 一份独立的病理学评论 将进行，以提供统一的组织学分类， 当有既往病史时，区分原发性癌症和转移性癌症 癌症。 将进行多因素logistic回归分析， 为了评估每个因素的影响，同时考虑所有其他因素 并评估影响修改。 结果应 阐明了鲜为人知的致病因素与 唾液腺癌的发展，并帮助解释最近 观察到这些癌症的发病率不断上升。

A population-based case-control epidemiologic study will be conducted to investigate risk factors associated with the incidence of salivary gland cancer. Incident cases of salivary gland cancer, diagnosed between October 1, 1990 and December 31, 1993, will be identified through rapid case ascertainment systems established under the auspices of two of the California Tumor Registry regional registries. The cases, who will number approximately 285, will be compared to an equal number of controls selected randomly from the general population and frequency-matched to the cases on the basis of five-year age groups. Controls age 20-64 will be identified through random-digit dialing processes. Controls age 65-79 will be identified through the records of the Health Care Finance Administration. Telephone interviews will be conducted using a structured questionnaire administered by a trained interviewer. The questionnaire will include items covering exogenous exposures, medical history, and selected dietary,k lifestyle, and sociodemographic factors. An independent pathology review will be conducted to provide a uniform histologic classification and to distinguish primary cancers from metastases when there is a prior history of cancer. Multiple logistic regression analyses will be performed in order to assess the effects of each factor while taking all other factors into account and to assess effect modification. The results should elucidate the little known etiologic factors associated with the development of salivary gland cancer and help to explain the recently observed increasing incidence of these cancers.