VECTOR MAPPING OF MYOCARDIAL ACTIVATION

室性快速性心律失常每年导致40万人死亡 在美国，这种机制和途径涉及 心律失常尚未完全阐明， 妨碍了治疗 申请人已经开发了一种技术， “矢量映射”，它可以准确地确定方向 心肌脉冲传播的正交记录求和 双极电描记图 第一部分提出的实验 这一应用将进一步完善这一新方法。 这种技术与等时线制图相结合， 用于表征传导并识别折返， 实验性和临床心肌梗死。 项目1将 处理载体的进一步技术发展 映射技术;特别是检查瞬时 向量。 这将为今后的实验打下基础 利用向量映射。 项目2将审查 将矢量映射与标准映射相结合的优点 等时技术定位心室肌起源部位 心动过速 这可能表明矢量映射 提高了心动过速标测的速度和准确性， 导致其在探针标测中广泛临床应用 心律失常手术中的室性心动过速。 在项目 3、矢量映射识别局部模式的能力 传导将与标准技术结合使用 研究与纤维相关的均匀和非均匀各向异性 实验性心肌梗死和正常心肌的定向 人体心外膜 这些研究将增加 了解异常时冲动传导的细节 心肌，并显示这种传导如何可能与 心律失常的发展。 在项目4中，矢量和 将采用等时线制图， 心室折返回路的解剖学通路 心肌 希望除了改善 临床绘图的速度、准确性和可用性 室性心动过速，本基金的研究将改善 了解参与的途径和机制， 折返性心律失常，并导致更好的方向 心律失常手术与替代治疗选择 接近。

Ventricular tachyarrhythmias result in 400,000 deaths annually in the U.S. The mechanisms and pathways involved in such arrhythmias have not been totally clarified and this has hampered therapy. The applicant has developed a technique, "vector mapping", which can accurately determine the direction of myocardial impulse spread by summing orthogonally recorded bipolar electrograms. Experiments proposed in the first portion of this application will further refine this new methodology. This technique in combination with isochronal mapping will then be used to characterize conduction and identify reentry in experimental and clinical myocardial infarction. Project 1 will deal with the further technical development of the vector mapping technique; specifically examining instantaneous vectors. This will lay the ground work for future experiments utilizing vector mapping. Project 2 will examine the advantages of combining vector mapping with standard isochronal techniques in localizing sites of origin of ventricular tachycardia. This may demonstrate that vector mapping improves the speed and accuracy of tachycardia mapping and lead to its widespread clinical use in probe mapping of ventricular tachycardia during arrhythmia surgery. In Project 3, the ability of vector mapping to identify patterns of local conduction will be used in combination with standard techniques to examine uniform and non-uniform anisotropy related to fiber orientation in experimental myocardial infarction and normal human epicardium. These studies should increase the understanding of the details of impulse conduction in abnormal cardiac muscle and show how such conduction may be related to the development of arrhythmias. In Project 4, vector and isochronal mapping will be employed in an attempt to identify the anatomic pathways of reentrant circuits in ventricular myocardium. It is hoped that in addition of improving the speed, accuracy and availability of clinical mapping of ventricular tachycardia, the studies in this grant will improve the understanding of the pathways and mechanisms involved in reentrant arrhythmias and lead to the better direction of arrhythmia surgery and selection of alternative therapeutic approaches.