IMPROVED BIOCOMPATIBILITY OF INTRAOCULAR LENSES

人工晶状体植入物已经恢复了白内障的视力 病人。植入物提供了视力，而不是 扭曲或放大，如因佩戴而产生的视觉 厚镜片眼镜或隐形眼镜。然而，就像在 所有其他可植入的装置，都有问题 人工晶状体与眼组织的相互作用(S)。 晶状体与角膜不经意的接触 在手术时或以后植入时的内皮 由患者携带，会造成严重而无法挽回的后果 角膜内皮单层受损。在这个项目中 我们计划以共价方式连接亲水性聚合物和 人工晶状体表面的粘弹性化学物质 材料。此过程不会损坏机械或 镜片的光学性能，但将改善其 生物相容性。这样的人工晶状体表面修饰 与镜片佩戴有关。这一过程将使 植入人工晶状体的可能性更大 改善视力的患者终身佩戴的数量。

Intraocular lens implants have returned vision to cataract patients. The implant provides visual acuity which is not distorted or magnified as is vision resulting from wearing thick-lensed spectacles or contact lenses. However, as with all other implantable devices, there are problems with the interaction of the synthetic lenses with eye tissue(s). Inadvertant contact between the lens and the corneal endothelium at the time of surgery or later when the implant is being carried by the patient, can cause serious and irreparble damage to the corneal endothelial monolayer. In this project we plan to covalently attach hydrophilic polymers and visco-elastic chemicals to the surface of intraocular lens materials. This process will not damage the mechanical or optical properties of the lenses, but will improve their biocompatability. Such intraocular lens surface modifcations associated with lens wear. This process will make the implantation of an artificial lens feasible for even greater numbers of patients to wear for a lifetime of improved vision.