Clinical research translation in fluorescence-guided surgery of brain cancer: developing a surgical endoscope with enhanced contrast

这项提议旨在通过开发一种新的神经外科光学成像设备来提高脑癌患者的预期寿命。这项技术将改变最近开发的荧光引导手术程序，在这种手术程序中，肿瘤被赋予人工荧光。我们最先进的技术将增强荧光检测，超越视觉感知，帮助移除难以检测的小癌细胞群，从而实现更准确的肿瘤手术切除。

This proposal aims to improve the life expectancy of brain cancer patients by developing a new neurosurgical optical imaging device. The technology will transform the recently developed fluorescence-guided surgery procedure, where the tumour is endowed with artificial fluorescence. Our state-of-the art technology will enhance the fluorescence detection beyond visual perception to help remove hard-to-detect small cancer cell clusters, resulting in more accurate surgical removal of tumours.