Personalised Pulsatile Materials (PPM)

该项目旨在开发一种突破性的材料：功能性多孔聚合物，能够以预先设计的节奏在预先设计的持续时间内完全自主地膨胀和收缩其体积。该奖学金的目标是为医疗应用生产生物相容性节律（脉动）材料。特别是在时间药物疗法中控制/靶向药物递送，以治疗在发病机制中具有既定振荡节律的疾病，例如关节炎（英国1000万人）、十二指肠溃疡（英国10人中有1人）、癌症（英国所有死亡人数中的1 / 4）和心血管疾病（英国4人中有1人）。在再生医学中，用于机械反应组织（如骨和血管系统），以促进细胞活性和机械健壮和生物功能组织（器官）的组装。拟议的方法包括与BDD （http://www.bddpharma.com/）和国际公认的学术合作伙伴的合作。这将促进进展、知识传播、降低风险并确保材料适合最终用户驱动的适合用途产品的开发，并将加速研究成果向医疗保健应用的转移。该提案建立在使用聚合物底物的化学振荡器的突破性发现（Chem comm 2014）和生物相容性智能水凝胶的深入研究（Adv Mater Sci Eng 2015）的基础上。项目持续时间为2年，该方法有3个工作包（WP）。WP1与Twente大学vanso教授的团队合作，解决了原理验证的自主聚合物材料的合成和实验验证。在WP2中，与BDD公司合作，对材料进行表征和验证，以满足最终用户的需求和法规要求。WP3与贝尔格莱德大学Kolar-Anic教授小组合作，重点开发预测性物理化学模型，以帮助实验研究和促进设计适合患者的材料。该提案与医疗技术重大挑战（开发未来疗法；优化治疗）以及先进材料和未来制造技术研究领域保持一致。

The project aims to develop a ground-breaking class of materials: functional porous polymers able to expand and collapse their volume fully autonomously in a predesigned rhythm for a predesigned duration. The goal of this fellowship is to produce biocompatible rhythmic (pulsatile) materials for medical applications. In particular, for controlled/targeted drug delivery in chronopharmacotherapy to treat diseases with established oscillatory rhythms in their pathogenesis, e.g. arthritis (10 million people in UK), duodenal ulcers (1 in 10 people in UK), cancer (1 in 4 of all deaths in UK) and cardiovascular diseases (1 in 4 adults in UK). Also, for mechanoresponsive tissues (e.g. bone and the vascular system) in regenerative medicine to facilitate cell activity and the assembly of mechanically robust and biologically functional tissue (organs). The proposed methodology incorporates collaboration with BDD (http://www.bddpharma.com/) and internationally recognised academic partners. This will enhance progress, knowledge dissemination, mitigate risks and ensure the materials are suitable for end-user driven development of fit-for-purpose products, and will accelerate transfer of research outcomes to healthcare applications. The proposal is built on the ground-breaking discovery of chemical oscillators employing polymeric substrates (Chem Commun 2014) and in-depth studies of biocompatible intelligent hydrogels (Adv Mater Sci Eng 2015) resulting from CAF2009. The project duration is 2 years and the methodology has 3 work packages (WP). WP1 in collaboration with Professor Vancso's group, Twente University, addresses the synthesis and experimental validation of proof-of-principle autonomous polymeric materials. In WP2, in collaboration with BDD company, characterisation and validation of the materials is pursued to meet end-user needs and regulatory requirements. WP3 in collaboration with Professor Kolar-Anic's group, Belgrade University, focuses on the development of predictive physico-chemical models to aid experimental studies and facilitate the design of patient-tailored materials. The proposal is aligned with Healthcare Technologies Grand Challenges (Developing Future Therapies; Optimising Treatment) and Advanced Materials and Future Manufacturing Technologies areas of research.