CYCLODEXTRINS FOR SLOW-RELEASE ANTIBIOTIC COATING

描述：(改编自申请人的摘要)。据报道， 以聚合物为基础的植入性设备，如尿路 导管、人工晶状体、血管移植物和起搏器导线 包括80%的非骨科可植入装置，其数量为 预计未来还会增加。不幸的是，聚合物表面 天生就会受到以设备为中心的惊人高感染率的影响。 因为用常规抗生素进行全身治疗不会 结果局部浓度足够高，可以有效地治疗 这种类型的感染，昂贵的再次手术器械取出是 几乎总是必要的。因为这次严重的手术 植入物的并发症，抗生素缓释表面治疗 设备将缓解可植入设备的一个主要问题。 这个第一阶段研究项目的目标是利用生物计量 系统公司的S专有光固定化技术 特异性环糊精包合物的共价固定化 抗生素到模型疏水支持基质上，如尿液 导尿管。这些缓释抗菌涂层将 有可能降低以设备为中心的感染的发生率，并 与目前使用的程序相比，显示出明显的优势。

DESCRIPTION: (Adapted from the Applicant's Abstract). It is stated that polymer-based implantable devices, such as urinary tract catheters, intraocular lenses, vascular grafts,and pacemaker leads comprise 80% of all non-orthopedic implantable devices and the number is expected toincrease in the future. Unfortunately, polymer surfacesare inherentlysubject to alarmingly high device-centered infection rates. Since systemic treatment with conventional antibiotics doesnot resultin sufficiently high local concentrations to effectively treat this type of infection, expensive reoperative device removal is virtually always necessary. Because of the serious surgical complications, antibiotic slow-release surface treatments for implantable devices would alleviate a major problem with implantable devices. The goal of this Phase I research project is to utilize Bio-Metric Systems, Inc.'s proprietary photoimmobilization technology to covalently immobilize cyclodextrin inclusion complexesof specific antibioticsonto model hydrophobic support matrices, such as urinary tract catheters. These slow-release antimicrobial coatings will potentially reduce the incidence of device-centered infections and exhibit distinct advantages over currently used procedures.