HIGHLY SENSITIVE FIBER OPTIC SENSOR FOR CANCER DIAGNOSIS

基于荧光的光动力疗法已经证明了它的潜力， 识别异常细胞、评估预后和监测疾病。 但是目前的光动力仪器太昂贵，太复杂， 缺乏早期肿瘤诊断所需的灵敏度。 的主要挑战 这项技术的关键是建立一个光纤系统， 有效地将信号从背景中分离出来，准确地分辨出 荧光谱，并适当处理数据，以增加信号- 噪声比 为了满足这项技术的需求，Physical Optics Corporation (POC)提出了一种用于早期癌症的紧凑型多功能光纤系统 诊断. 该系统使用POC的新型全息滤波器，波长 波分复用器（WDM）和光信号处理。 所得 探测器将非常紧凑和高度坚固，需要很少的 上维护 POC的光纤系统将很容易部署， 临床条件。 所提出的方法允许检测荧光- 组织中标记物浓度低至1.3 ng/ml。 这是两份订单 比现有的系统更好。

Fluorescence-based photodynamic therapy has proved its potential for identifying abnormal cells, assessing prognosis, and monitoring disease. But the present photodynamic instruments are too costly, too complex, and lack sensitivity required for early tumor diagnosis. The major challenge of this technology is to build an optical fiber system which can efficiently isolate the signal from the background, accurately resolve the fluorescence profile, and properly process the data to increase signal-to- noise ratio. In response to the need for this technology, Physical Optics Corporation (POC) proposes a compact versatile fiber-optic system for early cancer diagnosis. This system uses POC's novel holographic filters, wavelength division multiplexers (WDM), and optical signal processing. The resulting detector will be extremely compact and highly rugged, requiring little maintenance. POC's fiber optic system will be easy to deploy under clinical conditions. The proposed method allows detection of fluorescence- marker concentrations as low as 1.3 ng/ml in tissues. This is two orders of magnitude better than the existing systems.