LASER TREPHINATION OF THE CORNEA

有人提议开发一种非接触式激光器 角膜环钻术。这种激光器可以极大地提高 30,000多例角膜移植的结果 在美国每年一次。在第一阶段， 研究人员正在对现有的实验室高频激光器进行改造，以用于角膜 钻孔，展示可重现的、高质量的圆形 角膜按钮，以比较愈合率、强度和质量 激光切割和机械切割角膜的动物模型，以及 从概念上设计了一种适合临床使用的激光样机。 第一阶段的第二阶段将包括工程 原型激光器的设计、建造和测试；用于 进一步的动物研究；用于切割人类角膜的供体角膜 移植手术。第二阶段完成后的目标是 一种可用于人体移植临床试验的激光器 对供者(身体或眼库眼)和受者进行环钻 (病人)组织。

It is proposed to develop a laser to perform non-contact trephination of the cornea. This laser could greatly improve the outcome of more than 30,000 corneal transplantations performed yearly in the United States. During Phase I, the aims of the research are to modify an existing laboratory HF laser for corneal trephination, to demonstrate reproducible, high quality circular corneal button, to compare healing rate, strength, and quality of laser-cut and mechanically cut cornea in animal models, and to conceptually design a prototype laser suitable for clinical use. The Phase II continuation of Phase I would include engineering design, construction, and test of the prototype laser; use in further animal studies; use to cut donor corneas for human corneal transplantations. The goal upon completion of Phase II is to have a laser ready for clinical trials in human transplantations trephining both donor(cadaver or eye bank eye) and recipient (Patient) tissue.