A METAL-OXIDE, CHARACTERISTIC-LINE X-RAY IMAGING SOURCE

需要一种冠状动脉疾病筛查方法 不需要动脉导管的风险。 数字减影 使用碘-K-边缘减影的X射线照片遭受低X射线 强度和需要大的碘浓度，排除非 侵入性技术 需要更明亮的X射线源。 我们 建议对金属氧化物进行评估， 特征线X射线发射器。 两种类型的设备将 考虑：（1）高电流脉冲X射线枪与金属- 氧化物涂层薄靶窗口，（2）市售x- 带有改进的金属氧化物涂层旋转阳极的射线管。 这些源有望产生一个有用的通量的K-边缘 二色性的约50倍大于 滤过韧致辐射肺 我们还开发了一台电脑 模拟碘-K-边二色性，其确定 用特定X射线探测器成像所需的X射线通量 系统 这种模拟加上对 特征线x射线生产我们的来源，表明， 碘-K-边缘二色色谱法是可能的。 我们将在我们的 处置关键研究设施的瓦里安协会， 斯坦福大学直线加速器中心和阿德尔菲技术公司。 这包括X射线检测设备、X射线源和 气相沉积设备。 我们开发了一种数字化X光 成像系统，也可用于这项工作。 Adelphi Technology Inc.拥有丰富的经验，开发先进的x- 用于医疗、科学和工业应用的射线源。 一 基于所述特征的医学诊断成像系统- 线源正在开发这里承诺一个中等成本的非- 筛选动脉粥样硬化侵入性方法。

There is a need for a coronary-artery disease screening method not requiring the risk of an arterial catheter. Digital-subtraction radiographs using iodine-K-edge subtraction suffer from low x-ray intensities and require large iodine concentrations precluding non- invasive techniques. Brighter x-ray sources are needed. We propose to conduct an evaluation of metal oxides as characteristic-line x-ray emitters. Two types of devices will be considered: (1) A high-current pulsed x-ray gun with a metal- oxide-coated thin-target window, (2) A commercially available x- ray tube with a modified metal-oxide-coated rotating anode. These sources are expected to produce a useful flux for K-edge dichromography of approximately 50 times greater than that of filtered bremsstrah-lung. We have also developed a computer simulation of iodine-K-edge dichromography which determines the x-ray flux needed from imaging with a particular x-ray-detector system. This simulation together with an estimate of the characteristic-line x-ray production of our sources, indicate that iodine-K-edge dichromography is possible. We will have at our disposal critical research facilities of Varian Associates, the Stanford Linear Accelerator Center, and Adelphi Technology Inc. This includes x-ray detection equipment, x-ray sources, and vapor-deposition facilities. We have developed a digital x-ray- imaging system which is also available for this work. Adelphi Technology Inc. has extensive experience developing advanced x- ray sources for medical, scientific, and industrial applications. A medical diagnostic imaging system based upon the characteristic- line source being developed here promises a moderate-cost non- invasive method for screening atherosclerosis.