OMEGA-3 POLYUNSATURATED FATTY ACIDS FROM ALGAE

有一个显着的相关性， 二十碳五烯酸（EPA），降低冠状动脉 心脏病，选择性杀死某些癌细胞和缓解 类风湿关节炎的症状 我们提出了一种生物技术 用于从含EPA的油生产EPA的方法， 微生物在受控的发酵培养物中生长， EPA是目前可用的鱼油形式的替代品。 的 由阶段I中选择的微生物产生的油具有较高的 EPA含量，加热时稳定性增强，无“鱼腥味” 当与商业上可获得的鱼油源如 MaxEPA。 菌种选育及菌种改良策略 本提案中概述的内容应为 经济上可行的生产含EPA的油， 传统发酵技术。 而且 从这些微生物生产EPA提供了一个重要的 能够生产用于临床研究的标记EPA的好处 在短期内。 我们的总体目标，是生产一个上级环保局- 含有与之相容并可与之结合的油， 我们饮食中的典型食品， 环保署的属性可以实现更多的美国人没有 要求服用药丸。

There is a significant correlation between dietary supplements of eicosapentaenoic acid (EPA), with reduced incidence of coronary heart disease, selective killing of certain cancer cells and relief of symptoms of rheumatoid arthritis. We propose a biotechnological approach for the production of EPA containing oil from microorganisms grown in controlled, fermentation culture as an alternative to the fish oil form of EPA presently available. The oil produced by the microorganisms selected in Phase I had a higher EPA content, enhanced stability upon heating, and no "fishy" odor when compared to commercially available fish oil sources such as MaxEPA. The strain selection and culture improvement strategies outlined in this proposal should provide the foundation for the economically feasible production of EPA-containing oil using conventional fermentation technologies. Furthermore, the bioproduction of EPA from these microorganisms offers a significant bonus in being able to produce labelled EPA for clinical research in the near term. Our overall goal, is to produce a superior EPA- containing oil which is compatible with, and can be integrated into, typical food products in our diet so that the positive attributes of EPA can be realized by more Americans without the requirement of taking pills.