DOCOSAHEXAENOIC ACID FROM MICOALGAE

来自微藻的二十二碳六烯酸

• 批准号: 3495898
• 负责人: DAVID J KYLE
• 金额: $ 4.99万
• 依托单位: MARTEK BIOSCIENCE CORPORATION
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-01 至 1990-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3495898
• 关键词: algae; baby food; biotechnology; dietary supplements; fatty acid metabolism; human milk; nutrition related tag; stable isotope; unsaturated fatty acids

Docosahexaeoic acid (DHA) is the most abundant long chain polyunsaturated fatty acid in the grey matter of the brain. Although man has the capability of converting dietary linolenic acid into KHA, the evidence suggests that this process is slow. Consequently, at the time of most rapid brain development in the first few months of life, there is a critical demand for dietary DHA. Although DHA is provided to a nursing infant from mother's milk, most infant formulas are severely deficient in DHA. Attempts at supplementing infant formulas with fish oils have led to rejection due to the strong fishy odor and taste. Consequently, there is a need for an alternative DHA-containing oil as a nutritional supplement for infant formulations, and there is a need for further research on the uptake and metabolism of dietary DHA by both nursing mother and infant. Phytoplankton represent the largest depot of DHA on the Earth. The main goal of this research is to test the feasibility of using selected stains of DHA-producing microalgae for the production of an oil which can be used as a nutritional supplement for infant formulas and baby food. En route to this goal we will also develop the capability of producing 13C-labeled DHA; a nonradioactive research tool for the study of DHA uptake and metabolism using noninvasive nuclear magnetic resonance techniques.

二十二碳六酸（DHA）是最丰富的长链 大脑灰质中的多不饱和脂肪酸 虽然 人具有将膳食亚麻酸转化为KHA的能力， 有证据表明，这一进程是缓慢的。 因此，在 在生命的最初几个月，大脑发育最快的时间， 对膳食DHA有着迫切的需求。 虽然DHA被提供给 大多数婴儿配方奶粉都是用母乳喂养的婴儿，因此严重 缺乏DHA。 在婴儿配方奶粉中添加鱼类的尝试 油由于强烈的鱼腥味和味道而导致排斥。 因此，需要一种替代的含DHA的油作为润滑剂。 用于婴儿配方的营养补充剂，并且需要 进一步研究膳食DHA的吸收和代谢， 哺乳母亲和婴儿。 浮游植物是地球上最大的DHA储存库。主要 本研究的目的是测试使用选定的 用于生产油的产DHA微藻菌株，该油 可用作婴儿配方奶粉和婴儿的营养补充剂， 食物 在实现这一目标的过程中，我们还将发展以下能力： 生产13 C标记的DHA;这项研究的非放射性研究工具 使用非侵入性核磁共振技术研究DHA的摄取和代谢 共振技术