DEVELOPMENT OF POROUS COMPOSITE BIOMATERIALS

本提案的具体目的是证明以下方面的可行性： 生产具有弹性的复合植入材料 与聚二甲基硅氧烷基本相似，生物学特性 基本上类似于高表面能陶瓷，例如钙 羟基磷灰石 该复合材料将由保持在 多孔聚合物基体。 一种创新的纤维增强技术将 用于否定聚合物基质的性质。 保持 陶瓷的生物功能性，一种保存其 将利用暴露的表面区域。 原材料的影响， 工艺参数将被研究，样品将被彻底 使用体外技术表征。 在多孔复合材料领域 对于人体植入，这将提供一种柔软、柔韧的材料， 丰富的高能量表面积;从而允许应力转移和组织 以增强固定。 主要的商业应用将是 低应力承载植入物，用于颌面重建或 牙科修复应用。 如果这个项目的成果令人鼓舞 结果，免费赠款资金和内部资金将被利用 为了继续进行最佳变化的临床前体内测试， 技术.

The specific aim of this proposal will be to demonstrate the feasibility of producing a composite implant material with elastic properties substantially similar to polydimethylsiloxane, and biological properties substantially similar to high surface energy ceramics, such as calcium hydroxyapatite. The composite will consist of ceramic particles held in a porous polymeric matrix. An innovative fiber reinforcement technique will be utilized to negate the properties of the polymer matrix. To maintain the biological functionality of the ceramic, a technique of preserving its exposed surface area will be utilized. The effects of raw materials and processing parameters will be studied, and samples will be thoroughly characterized using in vitro techniques. In the field of porous composites for human implantation, this will provide a soft, flexible material with an abundant high-energy surface area; thus allowing stress transfer and tissue attachment to enhance fixation. The primary commercial application will be low-stress bearing implants, for use in maxillofacial reconstruction or dental restorative applications. If this project yields encouraging results, complimentary grant funds and internal finances will be utilized to proceed with preclinical in vivo testing of the best variations of the technology.