IMPLANTABLE STIMULATING MICROELECTRODES

随着神经刺激电极的发展，更多的 人们的注意力集中在研究可能的不良副作用上。 为他们的使用服务。对于具有以下特点的应用程序尤其如此 需要在高电流密度下进行长期刺激。组织的风险 损害，通常被认为与有毒物种有关 在电极组织界面处电化学形成的，一直是 对神经刺激的关注。这项拟议计划的目标是 开发适用于高比表面积“双电层”型惰性电极 用于神经元件的电刺激，从而有助于 治疗各种神经科疾病的电子设备的发展 精神错乱。在这个项目的第一阶段，我们准备并描述了 高比表面积金微电极，其电荷密度为 1mC/cm2/相。提出了进一步的研究建议，以改善 这些金电极的性能，并开发类似的电极 其他兼容材料。长期的体外和体内研究 将进行测试，并评估这些电极的性能。

As the development of neural stimulating electrodes is progressing, more attention has been directed towards studying possible adverse side effects attendant to their use. This is especially true for applications which require chronic stimulation at high current densities. The risk of tissue damage, which is generally believed to be associated with the toxic species formed electrochemically at the electrode tissue interface, has been a concern in neural stimulation. The objective of this proposed program is to develop high surface area "double layer" type inert electrodes suitable for the electrical stimulation of neural elements and thus to contribute to the development of electrical devices for treatment of various neurological disorders. In the Phase I of this program, we prepared and characterized high surface area gold microelectrodes which delivered a charge density of 1 mC/cm2/phase. Further studies are proposed here to improve the performance of these gold electrodes and to develop similar electrodes from other compatible materials. Both long term in vitro and in vivo studies will be carried out and performance of these electrodes will be assessed.