Co-operation between GATA2 mutation or expression and RAS signalling in AML

我们已经确定了一种基因GATA2，当它发生突变时，会导致白血病（血癌）。我们将在全球范围内从携带GATA2突变并发展为白血病的家庭和个人中收集样本，并将筛选导致白血病的其他遗传变化。我们还发现了一组新的患者，他们具有低GATA2活性，并且在RAS基因中也有突变，RAS基因是已知的导致白血病的因素。我们将确定它们是如何相互作用导致白血病的。

We have identified a gene GATA2 which, when mutated, can lead to leukaemia (blood cancer). We will collect samples worldwide from families and individuals that carry GATA2 mutations and have developed leukaemia, and will screen for other genetic changes that contribute to leukaemia. We have also identified a novel group of patients who have a low GATA2 activity and who also have mutations in the RAS gene, a known contributor to leukaemia. We will determine how these cooperate to cause leukaemia.