Co-ordinating the intrinsic and extrinsic arms of hematopoiesis

血液的细胞类型，如红细胞和白色细胞，是由骨髓中一种罕见的干细胞产生的。干细胞使用大量重要的主调节基因，这些基因按层次结构起作用，以促进血细胞分化过程。这项研究的目的是了解这些主调节器是如何单独发挥作用的，以及如何共同产生白色血细胞，这些血细胞是我们对微生物、疫苗接种和预防癌症的免疫反应所必需的。

The cell types of the blood, such as red and white blood cells, are produced in the bone marrow from a rare stem cell. The stem cell uses a handfull of important master-regulatory genes that act in a hierarchy to promote the blood cell differentiation process. This research aims to understand how these master-regulators function in isolation and together in producing the white blood cells that are required for our immune response to microbes, vaccination and to prevent cancer.