A comparative study of the pathophysiology of severe knowlesi and falciparum malaria

诺氏疟原虫引起猴疟疾，但最近发现它能感染人类，导致严重疾病和死亡，类似于恶性疟原虫。严重诺氏疟原虫的临床特征及其如何引起并发症的描述很少，了解这一点可以改善治疗和结局。在诺氏疟原虫患者中，我们希望描述其临床特征，导致严重疾病的能力，并测量1）血小板活化标志物和2）毛细血管阻塞和红细胞变形性，

Plasmodium knowlesi causes monkey malaria, but has recently been found to infect humans resulting in severe disease and death similar to Plasmodium falciparum. Clinical features of severe P. knowlesi and how it causes complications are poorly described and understanding this could improve treatment and outcomes. In patients with P. knowlesi, we want to describe the clinical features, the ability to cause severe disease, and measure 1) markers of platelet activation and 2) capillary obstruction and red cell deformability,