RESPIRATORY FACTORS IN BLOOD PRESSURE REGULATION

以前对实验室动物的研究表明， 所需回避任务的执行与 持续抑制呼吸频率低于静息水平， 有升压反应 这种模式促进了 动物实验性高血压与高钠 摄入 本项目研究了这一范式与监管的相关性， 人体血压 研制了一种便携式呼吸监护仪 这表明，有些人表现出抑制期， 呼吸（低于正常频率，潮气量无补偿）， 自然环境 这些事件发生得更频繁， 受试者在工作时比在家时更频繁， 他们和别人在一起的时候要比他们一个人的时候好。 抑制性呼吸 人类也被发现伴有血压升高， 而不是心率 然而，血压反应不是通过 通过肌肉交感神经活动，这表明它可能代表了一种效果， 血气变化对血管张力的影响。 因此，生理模式具有 被描述为“战斗或逃跑”反射的替代品， 结合高钠摄入，可能参与了 人类高血压适应性的发展。

Previous studies with laboratory animals have shown that periods of hours between performance of required avoidance tasks are associated with sustained inhibition of breathing frequency below resting levels, together with a pressor response. This pattern potentiates the development of experimental hypertension in animals when combined with a high sodium intake. This project investigates the relevance of this paradigm to regulation of human blood pressure. An ambulatory respiration monitor has been developed and refined, which has shown that some humans exhibit periods of inhibitory breathing (subnormal frequency without compensation in tidal volume) in the natural environment. These episodes occur more frequently when subjects are at work than when they are at home, and more frequently when they are with others than when they are alone. Inhibitory breathing by humans has also been found to be accompanied by increased blood pressure, but not heart rate. The blood pressure response is not, however, mediated via muscle sympathetic activity, suggesting that it may represent an effect of blood gas changes on vascular tone. Thus, a physiological pattern has been described that is alternative to the "fight or flight" reflex and that, in combination with high sodium intake, may participate in the development of hypertensive adaptations in humans.