MOLECULAR RECOGNITION OF LIPIDS AND LIPOPHILES BY CYCLODEXTRIN DERIVATIVES

羟丙基环糊精，葡萄糖的化学衍生物 低聚糖起源于切段，形成水溶性。 具有亲脂性的络合物。因为这些衍生品也是无毒的 它们已被用作药物增溶剂，并取得了足够的成功，符合资格 它们将被考虑纳入下一版美国 药典/国家药典。由于羟丙基环糊精 化学单体的无定形混合物，因此很难 目前，该科的工作重点是 制备条件对其性能的影响。这个 研究了环糊精的反应活性，并对其进行了表征。 详细分析，这些混合物和类似混合物的几种成分 被分离为化学个体，结晶和它们的晶体 结构已确定。

Hydroxypropyl Cyclodextrins, chemical derivatives of glucose oligosaccharides, which were originated in the section, form water soluble complexes with lipophiles. Since these derivatives are also non-toxic they have been used as drug solubilizers with enough of success to qualify them for consideration to be included in the next edition of US Pharmacopea/National Formulary. Since hydroxypropyl cyclodextrins are amorphous mixtures of chemical individua and thus difficult to characterize, the present work of the section has been focused on the effects which preparative conditions may have on their properties. The reactivity of cyclodextrins was investigated, the mixtures subjected to a detailed analysis, several components of these and of similar mixtures were isolated as chemical individua, crystallized and their crystal structure determined.