RESPIRATORY FACTORS IN BLOOD PRESSURE REGULATION

以前的动物研究表明，血压对 高钠摄入与持续呼吸抑制相关 是由厌恶性行为条件反射造成的 本项目旨在 为了识别人类受试者的紧张性通气的个体差异， 作为个体血压对高钠摄入反应的预测指标。 已经设计了一种呼吸监测器，其记录潮气量， 在自然环境中行走受试者的呼吸率。 监视器 将感应体积描记法与便携式 微处理器可以连续数天记录呼吸测量值。 研究表明，在24小时内， 呼吸频率、潮气量和每分钟通气量。 日分析 变化显示潮气量和每分钟通气量显著 在迄今为止研究的所有受试者中， 没有一致的主题内日夜！呼吸差异 频率. 相比之下，受试者内变异系数 (sd/平均值）的呼吸频率在白天显著更高 而潮气量和每分钟通气量则不一致 昼夜差异在这种变化的措施。 这些观察结果 提出了速率和潮气量不同生理控制， 为呼吸相关性的持续研究提供基础 血压反应的变化。

Previous studies with animals have shown that blood pressure response to high sodium intake is correlated with sustained respiratory suppression resulting from aversive behavioral conditioning. The present project seeks to identify individual differences in tonic ventilation of human subjects as a predictor of individual blood pressure response to high sodium intake. A respiration monitor has been devised which records tidal volume and breath-rate of ambulatory subjects in the natural environment. The monitor integrates methodology of inductive plethysmography with a portable microprocessor which can record respiratory measures continuously for days. Studies have shown significant differences between individuals in 24-hour breathing rate, tidal volume, and minute ventilation. Analysis of diurnal variations show that tidal volume and minute ventilation are significantly greater during the day than at night in all subjects studied to date but there are no consistent within-subject day-night !differences in breathing frequency. By contrast, the within-subject coefficient of variation (sd/mean) of breathing frequency is significantly greater during the day than at night, while tidal volume and minute ventilation show no consistent day-night differences in this measure of variability. These observations suggest differential physiological control of rate and tidal volume and provide the basis for continued investigation of respiratory correlation of variations in blood pressure response.