STRUCTURE-FUNCTION RELATIONSHIPS IN HEMOGLOBIN AND ERYTHROCYTES

本项目的重点是涉及管理约束力的机制， 氧气转化为血红蛋白以及氧气向组织的运输。重点 被放置在这些功能受损的方式上，并随着 “，e.这些研究集中在血红蛋白的氧化， 产生非功能性血红蛋白，同时释放 氧自由基缺氧条件下这些氧化过程的增强 作为组织和器官的可能来源， 在衰老过程中会加剧。研究还包括 其针对整个红细胞的稳定性， 红细胞膜

This project focuses on the mechanism involved in regulating the binding of oxygen to hemoglobin and the transport of oxygen to the tissues. Emphasis is placed on ways in which these functions are impaired and change with ",e. These studies have focused on the oxidation of hemoglobin, which produces nonfunctional hemoglobin and the simultaneous release of oxyradicals. The enhancement of these oxidative processes under hypoxic conditions is being explored as a possible source of tissue and organ damage, which would be exacerbated during aging. Studies are also included which are directed at the stability of the entire erythrocyte and the erythrocyte membrane.