EFFECT OF AGING ON THE IMMUNE RESPONSE

1)影响小鼠和人T δ诱导的因素 以及IgD可用于增强抗体的可能性 在老年小鼠中产生，可能与IL-2组合。 老年人记忆B细胞发育及其T细胞调节 将比较年轻小鼠（Drs. G. J. Thorbecke和R.F. Coico）。 2)研究了聚乙烯醇的表面性质、数量和功能活性， 老年和年轻小鼠和人类皮肤中的朗格汉斯细胞， 和表面抗原表达（特别是Ia）的上调 抗原）对这些细胞的淋巴因子。 这些函数上的Ia表达式 表皮中的抗原呈递细胞受到极大损害， 年龄，这可能会影响平衡的帮助，抑制 T细胞对经皮肤呈递的抗原的应答 对皮肤肿瘤的反应（D. V. Belsito和G. J. Thobecke博士）。 3)各种T细胞的功能活性及其相互关系 老年小鼠免疫应答中细胞亚群的变化 表面性质 三个不同的特征 抑制细胞的类型和计数 前体（S.R.S.博士）Gottesman）。 4)老年小鼠胸腺前细胞的再生活性及 这些细胞表面的异质性 受体。 老年小鼠胸腺功能的评价 接受和繁殖移行的前胸腺细胞（R. Basch）。 5)趋化反应，内皮细胞粘附， 由粒细胞产生杀菌氧代谢物 以及淋巴因子和 腺苷对这些反应的影响与细胞膜有关， 细胞骨架性质（Drs. B. Cronstein和R.赫什霍恩）。

1) The factors influencing T delta induction in mice and humans and the possibility that IgD may be used to augment antibody production in aged mice, perhaps in combination with IL-2. Memory B cell development and its T cell regulation in aged and young mice will be compared (Drs. G.J. Thorbecke and R.F. Coico). 2) The surface properties, numbers and functional activity of Langerhans cells in the skin of aged and young mice and humans, and the upregulation of surface antigen expression (particularly Ia antigen) on these cells by lymphokines. The Ia expression on these antigen-presenting cells in the epidermis is greatly impaired with age and this may influence the balance of the helper to suppressor T cell in responses to antigen presented via skin and in the response to skin tumors (Drs. D.V. Belsito and G.J. Thobecke). 3) The functional activity and interrelation between various T cell subsets in the immune response of aged mice as related to cell surface properties. Further characterization of three different types of suppressor cells and enumeration of suppressor cell precursors (Dr. S.R.S. Gottesman). 4) The regenerative activity of prethymic cells in aged mice and the heterogeneity of these cells in terms of their surface receptors. Assessment of the ability of the thymus in aged mice to receive and propagate immigrant prothymocytes (Dr. R. Basch). 5) The chemotactic response, endothelial cell adherence, and generation of bactericidal oxygen metabolites by granulocytes from aged humans, as well as the influence of lymphokines an adenosine on these responses as related to cell membrane and cytoskeleton properties (Drs. B. Cronstein and R. Hirschhorn).